The urinary reflex involves the coordinated actions of the bladder, urethra, and sphincter muscles to regulate urination. When the bladder fills to 300-400mL, stretch receptors send signals to the spinal cord and brain. This triggers efferent signals through the pelvic nerve that cause the detrusor muscle to contract and the internal sphincter to relax, allowing urine to enter the urethra. Further stretching of the urethra sends feedback signals, and the external sphincter then relaxes to allow urination. Higher brain centers also facilitate or inhibit micturition through connections to the spinal micturition centers.