This dissertation addresses two problems in MIMO-OFDM communication systems: channel estimation and wireless location. For channel estimation, a pilot-tone based least squares algorithm is proposed. A unitary pilot matrix is designed to estimate the MIMO channel with minimum mean squared error and reduced complexity. For wireless location, a least squares approach is formulated to estimate location from time difference of arrival and angle of arrival measurements. The method is applied to WiMax networks and simulations demonstrate its accuracy.