Mitosis

The Great DivideThe Great Divide
05/04

To Be Answered…To Be Answered…
THINK:
 How many cells are you composed of?
 When an organism grows bigger do you
get more cells or just bigger cells or both?
 When do your cells divide the fastest?
Slowest?
 Do cells ever stop dividing?
 Are all cells capable of division and
replacement?

Why Would a Cell Divide?Why Would a Cell Divide?
 As cells absorb nutrients and get larger, the
volume of the cell increases faster than the
surface area
 This means that a cell can no longer absorb
nutrients and get rid of wastes fast enough to
support its demands (volume)
 So what’s a cell to do?
Solution: divide in 2!
Surface area
for exchange
not great
enough to
support cell’s
needs

When Would a Cell Divide?When Would a Cell Divide?
 Growth
 Repair or Replacement
 Cancer
Different cells divide at different rates:
 Most mammalian cells = 12-24 hours
 Some bacterial cells = 20-30 minutes

Getting Older…Getting Older…
 All cells are only allowed to complete a
certain number of divisions
 Then they die (programmed cell death)
How does cell division change over a lifetime?
 Childhood = cell division > cell death
 Adulthood = cell division = cell death
 The Later Years = cell division < cell death

Stages of the Cell CycleStages of the Cell Cycle
 2 stages = interphase (growth & replication of
DNA) & mitotic phase (division of cell into 2
daughter cells)
 Cell spends
about 90% of
the time in
interphase

InterphaseInterphase
 Divided into 3 phases:
 G1 (1st
gap) = small cell is absorbing nutrients,
growing & doing its job (i.e. making proteins)
 S (synthesis) = cell is continuing to grow &
duplicates its DNA (i.e. chromosomes) in
preparation for making duplicate cells during
mitosis
 G2 (2nd
gap) = cell keeps growing & doing its
job (i.e. making proteins); it grows too big…
solution = divide in 2

Mitosis: A Closer LookMitosis: A Closer Look
 Prior to entering the mitotic
phase, the cell has just
come out of interphase
 Replicated DNA during S
(synthesis)
 2 complete sets of
chromosomes that must
be distributed equally
between 2 cells = mitosis
Interphase

The Mitotic PhaseThe Mitotic Phase
 Equal distribution of 2 sets of chromosomes (DNA)
into 2 identical daughter cells
 Divided into 4 stages of Mitosis:
 Prophase
 Metaphase
 Anaphase
 Telophase
 Cytokinesis

Cell Cycle TidbitsCell Cycle Tidbits
How long is one cell cycle?
 Depends on the cell- skin cells = ~24
hours, nerve cells = never after
maturity, cancer cells = very short
 Remember: every cell only has a
certain # of divisions it can undergo,
then it dies = apoptosis (programmed
cell death)

ProphaseProphase
 Chromatin condenses
visible chromosomes
 Appear as sister
chromatids held together
by centromere
 Nuclear membrane
dissolves
 The centrioles migrate to
opposite poles & spindle
fibers form between them
 http://www.biostudio.com/demo_freeman_dna_coiling.htm

MetaphaseMetaphase
 Chromosomes
line-up on the
metaphase
plate
 Centromeres
are attached to
spindle fibers

AnaphaseAnaphase
 Centromeres divide
 Spindle fibers contract
 Result = sister
chromatids are pulled
away from one another
towards the poles

TelophaseTelophase
 The chromosomes
reach the poles
 Nuclear
membranes form
around the 2 new
nuclei

CytokinesisCytokinesis
 The cytoplasm
distributed equally
between the 2 new
cells
 In animals, a
cleavage furrow
forms from outside in
 In plants, a cell
plate forms from
inside out
PlantAnimal

What Mitosis Actually Looks LikeWhat Mitosis Actually Looks Like
Interphase
Prophase Metaphase
Anaphase
Telophase
http://www.sci.sdsu.edu/multimedia/mitosis/mitosis_gif2.html
http://science.nhmccd.edu/biol/bio1int.htm

Summary of MitosisSummary of Mitosis

What Happens After Mitosis?What Happens After Mitosis?
 The cell
returns to
interphase
 Chromosomes
uncoil back
into chromatin
 The cycle
repeats itself
over & over…

At What Stage Are Our Cells At In The Cell Cycle?At What Stage Are Our Cells At In The Cell Cycle?
 Different cells can
be in different
stages
 Interphase
 Mitosis:
 Prophase
 Metaphase
 Anaphase
 Telophase
 Cytokinesis

Can You Identify the Stages of Mitosis?Can You Identify the Stages of Mitosis?
Put the
following
mitosis
stages in the
correct
sequence

The GuarenteeThe Guarentee
 The product of
mitosis is 2 cells
 The daughter cells
are identical to
each other & to the
mother cell
Mother
cell
Identical
daughter
cells
Why is this so
important?

The Daughter CellsThe Daughter Cells
 In humans, the 2
daughter cells will have
46 chromosomes (23
pairs)
 1 chromosome
originally from mom & 1
from dad
 Each chromosome is
said to have the same
gene sequence
Identical
daughter
cells

The Beauty of Asexual ReproductionThe Beauty of Asexual Reproduction
 Mitosis is a
form of
asexual
reproduction
 New
individuals are
produced by 1
parent & thus,
are identical to
their parent
Mother
cell
Identical
daughter
cells
Runners produces by
strawberries
Cuttings from plants
Budding by hydra & yeast

Mitosis

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