Modern Perl for the Unfrozen Paleolithic Perl Programmer discusses many changes to Perl and its ecosystem since 2001 when the caveman programmer fell into a glacier. Some key changes include Perl version 5.22, new language features like defined-or and subroutine signatures, and tools like Perlbrew, Plenv and cpanm. Modern web development uses Plack/PSGI instead of CGI.pm. The speaker recommends modules like JSON::MaybeXS, Moose/Moo and websites like CPAN Ratings, MetaCPAN and Perl Weekly to stay up-to-date.