Multidimensional indexes allow querying data across multiple dimensions. Grid files partition data into grid cells and store pointers to data within each cell, allowing quick retrieval of data matching queries on individual or ranges of dimensions. Partitioned hash functions map multiple dimensions to a single hash value, grouping related data. Tree structures like kd-trees and quad trees recursively split the data space, allowing efficient nearest neighbor and spatial queries. R-trees group regions hierarchically to support region queries on multidimensional data.