This document discusses optimizing MySQL performance when deployed in cloud environments. Some key points: 1) Deploying MySQL in the cloud presents new challenges like increased IO latency from network storage, but also opportunities to scale horizontally across multiple servers. 2) InnoDB performance is particularly important to optimize, through techniques like reducing mutex contention, increasing IO throughput, and using patches that improve handling of higher latency storage. 3) Benchmarks show that direct attached storage outperforms network storage, and optimizations like IO threads and capacity tuning can help mitigate higher latencies of network storage. Virtualization also incurs some performance overhead.