On the application of
multi-agent systems in
health care
Dr. Antonio Moreno
ITAKA-Intelligent Tech. for Advanced Knowledge Acquisition
Computer Science and Mathematics Dep.
Univ. Rovira i Virgili, Tarragona
http://deim.urv.cat/~itaka
                                          Sevilla, June 14th-15th 2010
Outline of the talk

   Introduction
   Health care areas where agents have
   been applied
   K4Care: agent-based provision of Home
   Care services
   Benefits of the application of agents in
   health care problems
Characteristics of Health Care problems
   Distributed knowledge
     E.g. different units of a hospital
   Coordinated effort
     E.g. receptionist, general and specialised
     doctors, nurses, tests personnel, ...
   Complex problems
     E.g. patient scheduling
   Need to manage different types of
   knowledge
     Medical, organisational, procedural
Why use MAS in Health Care?

 MAS are inherently distributed
  Agents can coordinate their activities, while
 keeping their autonomy and local data
  Dynamic and flexible distributed problem
 solving mechanisms
  Use of personalisation techniques
   Knowledge-based behaviour of the system
Main application domains
5


        1‐Medical data management                                              3‐Planning and resource allocation
       National electronic Library for Health (NeLH)                                         Agent.Hospital (simulation)
       Management of palliative patients (PalliaSys)                                      CARREL (transplant management)
          Virtual Electronic Patient Record (VEPR)                                        Medical Information Agents (MIA)
     Context‐aware Hospital Information System (CHIS)                                 Medical Services Coordination (MeSSyCo)


                                                   5‐Composite Systems
                                                  SHARE‐IT (assistive technologies)
                                                         K4Care (Home Care)
                                                Geriatric Ambient Intelligence (GerAmI)

         2‐Decision support systems                                               4‐Remote care, telemedicine
                Singh’s intelligent assistant                                              Aingeru (elder monitoring)
                 HealthAgents [Microart]                                                   INCA (Community services)
              Health Care Services (HeCaSe)                                            Medical Contact Centres [Koutkias]
                                                                                      Monitor chronic patients [Cervantes]
1-Medical data management
 This area includes different kinds of systems:
  Information agents that collect, filter and analyse
  medical information available in electronic
  resources
  Agents that provide a transparent access to
  physically distributed information sources
     Different medical organisations, or different units within
     a hospital
  In general, intelligent management of the personal
  and medical information in the Electronic Health
  Record of a patient
2-Decision support systems
 These systems aim to assist the professionals in
 the decisions to be taken during the healthcare
 process.
   E.g. help in the diagnosis phase, or in the definition and
   execution of the most appropriate personalised
   treatment.
 Agents can also perform routine actions, such as
 checking periodically the patient state, or waiting
 for the results of a medical test to be available
 They usually perform complex reasoning
 processes
3-Planning and resource allocation

 Systems in which professionals and/or
 medical resources are represented by
 autonomous agents
 The basic aspect is the coordination of their
 activities to take appropriate decentralised
 scheduling decisions in medical centres
   E.g. patient scheduling
4-Remote care, Telemedicine

 In most cases, the basic aim of the system is
 to monitor continuously the state of the
 patients, allowing permanent care
 Main elements of the system:
   Collection of sensors
   Analysers of signals from sensors, problem
   detection
   Generation of alarms and reports for medical staff
5-Composite systems

 Agent-based platforms that integrate
 different ICTs and Artificial Intelligence
 techniques in order to provide an efficient
 coordination of the activities to be performed
 to provide an efficient health care to a
 particular kind of patients
K4Care European project

 2006-2009, 13 partners, coordinated by
 URV
 The aim of the K4Care European
 project was to provide a Home Care
 model, as well as to develop a prototype
 system, based on Web technology and
 intelligent agents, that provided the
 services defined in the model
K4Care Model: Structure
 1 Nuclear Structure + n Accessory Services


                      THE K4CARE MODEL

                                                  ...

          HCNS

             Actor                          Service
                         Data/Information
             Action                         Procedure
K4Care Model: Actors and Teams
K4Care architecture
K4Care Knowledge structures

  EHCR: Electronic Health Care Record
  APO: Actor Profile Ontology
  CPO: Case Profile Ontology
  Procedures
  FIP: Formal Intervention Plan
  IIP: Individual Intervention Plan
K4Care Ontologies (I)

 Actor Profile
 Ontology (APO)
   Types of actors
   Actions related to
   each role
   Platform services
   Procedures
   Documents
   ...
K4Care Ontologies (II)
 Case Profile Ontology (CPO)
   Diseases
   Syndromes
   Signs and symptoms
   Social issues
   Assessment tests
   Interventions
   ...
Procedures, FIPs and IIPs
 All the careflow procedural aspects are
 represented in SDA* (States, Decisions, Actions)
 Procedures are formal specifications of the way in
 which an administrative service (e.g. admit a new
 patient to the Home Care service) has to be
 implemented
 Formal Intervention Plans (FIPs) are formal
 structures representing the health care workflow to
 assist patients suffering form particular ailments or
 diseases
   Problem: application of guidelines to co-morbid patients
Definition of an
Individual Intervention Plan
K4Care platform features
 Agent-based Web-accessible platform that
 provides a set of basic Home Care services
   Admit a patient to the Home Care service
   Create an Evaluation Unit
   Assign an Evaluation Unit to a particular patient
   Assess the initial state of a patient
   Definition of an IIP for a patient
   Apply IIP to the patient
   ...
K4Care agent-based platform
Multi-agent system
 1 Actor Agent for each user, permanently
 running
 When the user logs in, a Gateway Agent is
 dynamically created
   Two-way communication Web-servlet-GA-AA
 When an Actor Agent has to manage the
 execution of a procedure/IIP, it creates
 dynamically a SDA-executor Agent
Agent-based execution of IIPs (I)
Agent-based execution of IIPs (II)
Agent-based execution of IIPs (III)
Agent-based execution of IIPs (IV)
Summary of K4Care main aspects
 Declarative (medical, organizational) and procedural
 knowledge
 Web-based interaction between agents and end-
 users
 Individual Intervention Plans allow practitioners to
 implement accurate and personalised sequences of
 actions for the treatment of a particular patient
 The architecture allows implementing agent-based
 coordination methods between the actors relevant in
 Home Care, which adapt their behaviour
 dynamically depending on the knowledge available
 in the platform
Positive aspects of MAS [in HC] (I)
  Modularity
    A complex problem is divided in subproblems
    which may be solved by autonomous units, with
    the appropriate coordination among them
  Efficiency
    Agents may be running in different computers,
    speeding up the resolution of the problem
  Decentralisation
    Less single point-of-failure risk than centralised
    systems
Positive aspects of MAS [in HC] (II)
  Flexibility
    The MAS components may change at run time,
    the tasks may be dynamically distributed
  Personalisation
    Personal agents may have information on the
    user preferences and adapt the system’s
    behaviour to them
  Distributed planning
    Use of coordination techniques for distributed
    problem solving
Positive aspects of MAS [in HC] (III)
 Monitoring, alarm management
   Continuous monitoring of personal and medical
   data, with immediate activation of emergencies
   when needed
 Proactivity
   Agents may perform tasks without requiring a
   constant intervention or request from the user
 Security
   Confidentiality of medical data
Recommended extra material
   Publications at http://deim.urv.cat/~itaka
   D.Isern, D.Sánchez, A.Moreno
   Agents applied in health care: a review
   International Journal of Medical Informatics, Vol. 70, pp.
   145-166, 2010
On the application of
multi-agent systems in
health care
Dr. Antonio Moreno
ITAKA-Intelligent Tech. for Advanced Knowledge Acquisition
Computer Science and Mathematics Dep.
Univ. Rovira i Virgili, Tarragona
http://deim.urv.cat/~itaka               Sevilla, June 14th-15th 2010
Agents – general definition

 Computational entities, capable of sensing
 the environment and acting proactively and
 autonomously upon it in order to satisfy their
 design objectives
 Can communicate with other agents to share
 information, coordinate their activities and
 cooperate to solve complex distributed
 problems
DBs, Electronic Health Care Record

  Data Base: with information about the
  K4Care actors as users of the K4Care
  Platform (e.g. contact information)
  EHCR: with the data about the Home-
  Care processes performed within the
  K4Care Platform
    Medical documents stored in XML
FIP for the
management
     of
hypertension

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On the application of multi-agent systems in Health Care

  • 1. On the application of multi-agent systems in health care Dr. Antonio Moreno ITAKA-Intelligent Tech. for Advanced Knowledge Acquisition Computer Science and Mathematics Dep. Univ. Rovira i Virgili, Tarragona http://deim.urv.cat/~itaka Sevilla, June 14th-15th 2010
  • 2. Outline of the talk Introduction Health care areas where agents have been applied K4Care: agent-based provision of Home Care services Benefits of the application of agents in health care problems
  • 3. Characteristics of Health Care problems Distributed knowledge E.g. different units of a hospital Coordinated effort E.g. receptionist, general and specialised doctors, nurses, tests personnel, ... Complex problems E.g. patient scheduling Need to manage different types of knowledge Medical, organisational, procedural
  • 4. Why use MAS in Health Care? MAS are inherently distributed Agents can coordinate their activities, while keeping their autonomy and local data Dynamic and flexible distributed problem solving mechanisms Use of personalisation techniques Knowledge-based behaviour of the system
  • 5. Main application domains 5 1‐Medical data management 3‐Planning and resource allocation National electronic Library for Health (NeLH) Agent.Hospital (simulation) Management of palliative patients (PalliaSys) CARREL (transplant management) Virtual Electronic Patient Record (VEPR) Medical Information Agents (MIA) Context‐aware Hospital Information System (CHIS) Medical Services Coordination (MeSSyCo) 5‐Composite Systems SHARE‐IT (assistive technologies) K4Care (Home Care) Geriatric Ambient Intelligence (GerAmI) 2‐Decision support systems 4‐Remote care, telemedicine Singh’s intelligent assistant Aingeru (elder monitoring) HealthAgents [Microart] INCA (Community services) Health Care Services (HeCaSe) Medical Contact Centres [Koutkias] Monitor chronic patients [Cervantes]
  • 6. 1-Medical data management This area includes different kinds of systems: Information agents that collect, filter and analyse medical information available in electronic resources Agents that provide a transparent access to physically distributed information sources Different medical organisations, or different units within a hospital In general, intelligent management of the personal and medical information in the Electronic Health Record of a patient
  • 7. 2-Decision support systems These systems aim to assist the professionals in the decisions to be taken during the healthcare process. E.g. help in the diagnosis phase, or in the definition and execution of the most appropriate personalised treatment. Agents can also perform routine actions, such as checking periodically the patient state, or waiting for the results of a medical test to be available They usually perform complex reasoning processes
  • 8. 3-Planning and resource allocation Systems in which professionals and/or medical resources are represented by autonomous agents The basic aspect is the coordination of their activities to take appropriate decentralised scheduling decisions in medical centres E.g. patient scheduling
  • 9. 4-Remote care, Telemedicine In most cases, the basic aim of the system is to monitor continuously the state of the patients, allowing permanent care Main elements of the system: Collection of sensors Analysers of signals from sensors, problem detection Generation of alarms and reports for medical staff
  • 10. 5-Composite systems Agent-based platforms that integrate different ICTs and Artificial Intelligence techniques in order to provide an efficient coordination of the activities to be performed to provide an efficient health care to a particular kind of patients
  • 11. K4Care European project 2006-2009, 13 partners, coordinated by URV The aim of the K4Care European project was to provide a Home Care model, as well as to develop a prototype system, based on Web technology and intelligent agents, that provided the services defined in the model
  • 12. K4Care Model: Structure 1 Nuclear Structure + n Accessory Services THE K4CARE MODEL ... HCNS Actor Service Data/Information Action Procedure
  • 13. K4Care Model: Actors and Teams
  • 15. K4Care Knowledge structures EHCR: Electronic Health Care Record APO: Actor Profile Ontology CPO: Case Profile Ontology Procedures FIP: Formal Intervention Plan IIP: Individual Intervention Plan
  • 16. K4Care Ontologies (I) Actor Profile Ontology (APO) Types of actors Actions related to each role Platform services Procedures Documents ...
  • 17. K4Care Ontologies (II) Case Profile Ontology (CPO) Diseases Syndromes Signs and symptoms Social issues Assessment tests Interventions ...
  • 18. Procedures, FIPs and IIPs All the careflow procedural aspects are represented in SDA* (States, Decisions, Actions) Procedures are formal specifications of the way in which an administrative service (e.g. admit a new patient to the Home Care service) has to be implemented Formal Intervention Plans (FIPs) are formal structures representing the health care workflow to assist patients suffering form particular ailments or diseases Problem: application of guidelines to co-morbid patients
  • 19. Definition of an Individual Intervention Plan
  • 20. K4Care platform features Agent-based Web-accessible platform that provides a set of basic Home Care services Admit a patient to the Home Care service Create an Evaluation Unit Assign an Evaluation Unit to a particular patient Assess the initial state of a patient Definition of an IIP for a patient Apply IIP to the patient ...
  • 22. Multi-agent system 1 Actor Agent for each user, permanently running When the user logs in, a Gateway Agent is dynamically created Two-way communication Web-servlet-GA-AA When an Actor Agent has to manage the execution of a procedure/IIP, it creates dynamically a SDA-executor Agent
  • 27. Summary of K4Care main aspects Declarative (medical, organizational) and procedural knowledge Web-based interaction between agents and end- users Individual Intervention Plans allow practitioners to implement accurate and personalised sequences of actions for the treatment of a particular patient The architecture allows implementing agent-based coordination methods between the actors relevant in Home Care, which adapt their behaviour dynamically depending on the knowledge available in the platform
  • 28. Positive aspects of MAS [in HC] (I) Modularity A complex problem is divided in subproblems which may be solved by autonomous units, with the appropriate coordination among them Efficiency Agents may be running in different computers, speeding up the resolution of the problem Decentralisation Less single point-of-failure risk than centralised systems
  • 29. Positive aspects of MAS [in HC] (II) Flexibility The MAS components may change at run time, the tasks may be dynamically distributed Personalisation Personal agents may have information on the user preferences and adapt the system’s behaviour to them Distributed planning Use of coordination techniques for distributed problem solving
  • 30. Positive aspects of MAS [in HC] (III) Monitoring, alarm management Continuous monitoring of personal and medical data, with immediate activation of emergencies when needed Proactivity Agents may perform tasks without requiring a constant intervention or request from the user Security Confidentiality of medical data
  • 31. Recommended extra material Publications at http://deim.urv.cat/~itaka D.Isern, D.Sánchez, A.Moreno Agents applied in health care: a review International Journal of Medical Informatics, Vol. 70, pp. 145-166, 2010
  • 32. On the application of multi-agent systems in health care Dr. Antonio Moreno ITAKA-Intelligent Tech. for Advanced Knowledge Acquisition Computer Science and Mathematics Dep. Univ. Rovira i Virgili, Tarragona http://deim.urv.cat/~itaka Sevilla, June 14th-15th 2010
  • 33. Agents – general definition Computational entities, capable of sensing the environment and acting proactively and autonomously upon it in order to satisfy their design objectives Can communicate with other agents to share information, coordinate their activities and cooperate to solve complex distributed problems
  • 34. DBs, Electronic Health Care Record Data Base: with information about the K4Care actors as users of the K4Care Platform (e.g. contact information) EHCR: with the data about the Home- Care processes performed within the K4Care Platform Medical documents stored in XML
  • 35. FIP for the management of hypertension