Open Notebook Science and Malaria
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The document discusses the application of open science to malaria research, highlighting the vast scale of the problem with millions of cases and deaths annually. It emphasizes the transition from traditional scientific methods to open notebook science, encouraging transparency and collaboration through tools like blogs and wikis. The text outlines the need for innovative, cost-effective solutions in drug design while engaging both machines and humans in the scientific process.
Open Notebook Science and Malaria
- 1. Open Notebook Science and Malaria Jean-Claude Bradley Drexel University September 6, 2007 Chemists Without Borders
- 2. Malaria is a Logical Application of Open Science Very large problem: 300-500 million cases per year with one million deaths Not a lucrative market: IP control less important
- 4. Open and Closed Science Traditional Lab Notebook (unpublished) Traditional Journal Article Open Access Journal Article Open Notebook Science (full transparency) CLOSED OPEN
- 5. Where is Science headed? WE ARE HERE
- 7. Self-organizing redundant processes Agents can participate with zero or near-zero cost (free hosted services – e.g. Google) Fully Open Access (Read and Write) Publication of all aspects of the scientific process: Open Source Science / Open Notebook Science How will this happen?
- 8. How can machines know what is important? Ask the humans
- 10. What chemists think is important in 2005
- 11. Find-A-Drug
- 12. Diketopiperazine Library Evolves to: on pot Ugi reaction/cyclization First iteration: Solid Support Synthesis
- 17. Telling the story of the failures
- 18. Experiments moved to wiki
- 20. Experiment Edits
- 21. Third Party Time-Stamp on Experiment Versions
- 23. How are people finding our experiments?
- 24. Molecules found by InChI
- 25. usefulchem.blogspot.com The blog as an integrative tool
- 26. usefulchem.wikispaces.com/Exp049 The wiki as the laboratory notebook
- 27. Graphical Mining of Data with JSpecView usefulchem.wikispaces.com/Exp070 (48h 7 min)
- 28. Processing Molecules on ChemSpider
- 29. The CombiUgi Project Focus on cheap starting materials and a product that precipitate easily from solution
- 30. Open Primary Research in Drug Design using Web2.0 tools (blogs, wikis, Second Life, mailing lists) Docking Synthesis Testing Rajarshi Guha Indiana U JC Bradley Drexel U Phil Rosenthal UCSF (malaria) Dan Zaharevitz NCI (tumors) Tsu-Soo Tan Nanyang Inst.
- 31. UsefulChem and Open Science in Second Life scifooliveson.wikispaces.com