Peptic ulcers are sores in the gastrointestinal lining, primarily caused by H. pylori bacteria and NSAID use, leading to gastric, duodenal, or esophageal ulcers. Symptoms include burning abdominal pain, nausea, and potential bleeding, while diagnosis is through endoscopy or GI series. Treatment involves medications to eradicate H. pylori, reduce stomach acid, and possibly surgery for severe cases.