Presentation of Can

• CAN GmbH – Center for Applied Nanotechnology GmbH
• Concepts from Science to Industry

• Dr. Frank Schröder-Oeynhausen

Centrum für Angewandte Nanotechnologie (CAN) GmbH 1

Nanotechnology
in Germany

Center for Applied Nanotechnology (CAN) GmbH 2

Nanotechnology
in Hamburg
Borstel: Lübeck: UKSH
UKE, HPI: Nanobiomedicine Lasercenter,
Nanobiomedicine, Nanobiomedicine
Molecular Imaging University HH:
Nanoparticle synthesis,
Nanomaterials,
Nanobiochemistry,
Energy Research,
DESY: Catalysis,
Characterisation, Nanostructures,
Dynamics on the Nanoanalytics, CAN GmbH
nanometer scale Nanodevices,
EMBL: Theory of Nanosystems
Activity: Nanobiochemistry of
proteins
GKSS:
huge
Membranes,
Medium Nanomaterials
TUHH:
small BNI: Nanomaterials for
Nanobiomedicine Transport Systems,
CNTs, Polymers, Fuel
Cell Systems
Center for Applied Nanotechnology (CAN) GmbH

Nanotechnology
Properties

Surface to
volume ratio
102
size
100
1 nm 1µm 1mm 1m
10-2
10-4
10-6
10-8
Optically
transparent


Company Profile
Mission

Our main expertise is on the production and
functionalization of nanoparticulate and nanocomposite
materials, encapsulation of active ingredients as well as
development of nanoparticle-based biological and
medical markers for the cosmetics-, consumables- and
pharma industry.

We produce nanoparticles of highest quality, offers
contract research and development services in the area of
nanotechnology and participates in national and
international research programs.
5 nm
Mission: We offer nanoparticles for your purpose!


Company Profile
General Conditions
Academia CAN GmbH Market

Science
Collaborative
Publications Research

Patents

Project Management Own
Products
Standardization

Prototyping
Contract
Benchmarking Research
Products


Company Profile
Concept
Business Model: Public Private Partnership (PPP)
Founded: November 2005
Location: Hamburg

Staff: 25 + 6 (today)
Sales: 1.318.000 € (2009)

Partners: Verein zur Förderung der Nanotechnologie e.V. (65,2 %)
Free and Hanseatic City of Hamburg (24,8 %)
University Hamburg (10 %)

Subsidiaries: Screening Port Hamburg GmbH. (80,2 %)

Head of Supervisory Board: Prof. Dr. Klaus-Peter Wittern

Chief Scientific Officer: Prof. Dr. Horst Weller
Chief Operation Officer: Dr. Frank Schröder-Oeynhausen


Business Segments

Fields of Business Transfer Model:

• I. Cosmetics / Flavours: Contract Research
Thickener, Emulsions, Encapsulation

• II. Medicine / Medical Technology:
Nanoparticles for Diagnostics Own Products
Drug Delivery Systems International Collaboration

Analytics / Toxicity Service Tox-Tests
Analyses of Nanostructures Service Analytics
Assay Development

• III. Technical Applications:
Security Labels Contract Research (conf.)
Nanostructured Functionalized Layers National Collaboration


Business Segment I: Cosmetics

Nanoparticles
• Synthesis of ZnO - and TiO2 - nanoparticles
Contract
• Modification of nanoparticles Research
Polymers
• Thickener für water- and oilbased systems
• Systems for hair-repair
• Emulsions
• Mucoadhesive polymers

Encapsulation
• Encapsulation of drugs and flavours
• Water/Oil - nanoemulsions
Contact:
Personal Care: Dr. Marcel Ruppert (ruppert@can-hamburg.de)
Hair Care: Dr. Marc Thiry (thiry@can-hamburg.de)


Business Segment II: Medicine
Nanoparticles: Properties
Ligands define stability and chemistry:
• Biocompatibility
• Coupling mechanisms

Core defines properties
depending on size:
• Colour
5 nm • Magnetism
• Conductivity
• Thermodynamics
5 nm


Nanoparticles: CANdot® Series A
Features
• Fluorescent Nanoparticles

• Emission max: 500 to 620 nm

• High reproducible properties

• Soluble in water or non-polar organic
solvents

• High physical and chemical stability
Structure
• CdSe/CdS/ZnS dots

• Core-shell-shell structure

• Scalable core size

• Core and core-shell particles available, too Own
Product

Nanoparticles: CANdot® Series M
Features
• Magnetic nanoparticles

• Diameter between 5 and 30 nm
Own
• Small size distribution
Product
• Soluble in water or non-polar, organic
solvents

Structure magnet
• FeOX nanoparticles

• Hydrophobic acids for organic solvents

• Hydrophilic polymers for water

• Doping possible


Nanoparticles: Synthesis
A) Vapour Deposition (PVD / CVD) “Hot Injection Process”
B) Sol-Gel Technique
C) Wet-Chemistry Advantages

• universal applicable

• well known

• broad temperature range

Disadvantages

• temperature profile hard to
control

• slow mixing after injection

• “up-scaling” difficult


A) Vapour Deposition (PVD / CVD) “Flow Synthesis”
B) Sol-Gel Technique
C) Wet-Chemistry


Nanoparticles: Properties

5 nm


Toxicity of Nanoparticles

quality
skin

lung

ligands
intestine

shells

ICC
shape

size
nanoparticle modification interaction


Toxicity of Nanoparticles
Example for studying the interaction between nanoparticles and cell system

• Red: Epithelial-cells (lung), stained with Draq5 (nucleus)
• Blue: CdSe-CdS nanoparticles with different blockcopolymer-labels, located in the cell
cytosol and the cell membrane

Service

Contact:
Toxicity: Dr. Thomas Frahm (frahm@can-hamburg.de)
20

EU project VIBRANT
• The goal of VIBRANT is the development of nano-
technology-based systems for diabetes diagnosis
and/or therapy. from the pharmaceutical industry.

• CAN and UHH will provide a contrast agent
providing a stable and high signal intensity, which is
highly specific to the cell type, but low toxicity,

http://www.fp7-vibrant.eu/
Ultimately, VIBRANT will deliver β-
cell specific, functionally optimized
nanoconstructs and defined know-how
for in vivo applications in non-human
Ihr Ansprechpartner:
primates and humans with regard to
Dr. Theo Schotten (schotten@can-hamburg.de)
quantification of BCM, imaging of

Specific coupling agent
The Nanocontainer
Superparamagnetic particle
Quantum Dots
Biocompatible Shell

Anchor/Linker

Ligand

~ 20 - 300 nm

Micelle or Vesicle

Centrum für Angewandte Nanotechnologie GmbH

Outline
• EU Framework 7 Large Scale Project
• Idea and coordination: CAN GmbH
• Duration: 7/2009 to 6/2013
• Grant: 8 Mio EUR
• Scientists from nine research institutes from five EU-countries
(Belgium, Spain, Denmark, Sweden and Germany

• Industrial Advisory Board: big pharma.

http://www.fp7-vibrant.eu/

International
Ihr Ansprechpartner:
Dr. Theo Schotten (schotten@can-hamburg.de) collaboration

The “Axis of Excellence”*

International
collaboration
*) R = 0.989! ;-)

Business Segment III: Technical Applications
Security Labels
CANdots® Series X as Security Labels:
Contract
• Activation of the host lattice by doping with rare-earth elements
• Reproducible Shape of Particles (spheres to ellipsoids, synthesis specific) Research
• Reproducible Size of Particles (7 to 40 nm, material- and synthesis specific) (conf.)
• Physical und Chemical Stability (photo stabilized, inert to high temperatures, acids, bases und
organic solvents)

Contact:
Polymers: Dr. Jan Niehaus (niehaus@can-hamburg.de)


New Concept of a Solar Cell

Quantum Dot-
Carbon Nanotube
Composites

B.Hernandez-Juárez, C. Klinke, A.Kornowski, H. Weller
Institute of Physical Chemistry. Universität Hamburg.


New Concept of a Solar Cell

Collaboration
e.g. Photovoltaics
h+ with Academia
e
e-
e
e
e
e
e h
CB
VB
conductive polymer


Business Model:
Collaborative Research Projects
Example: VIBRANT, EU-Project

• EU Framework 7 – NMP – Large Scale Project
Nanosciences, Nanotechnologies, Materials and New
Production Technologies

• Goal of the project: Development of marker systems for diabetes diagnostics
• Coordination: CAN GmbH
• Timeframe: 7/2009 to 6/2013
• Budget: about 8 Mio EUR
• Scientists from nine research institutes from five EU-countries (Belgium, Spain, Denmark,
Sweden and Germany)
• Industrial Advisory Board
• Internet: www.fp7-vibrant.eu

• Coordination of the application process (two step process)


Business Model:
Patents, Products
Intellectual Property Rights owned by CAN

1. Method for producing alkaline earth sulfate nanoparticles (Basolute I)
2. Process for preparing dispersible sulfate nanoparticles (Basolute II)
3. Luminescent core/shell nanoparticles
4. Core/shell nanoparticles suitable for (F)RET-assays
5. Synthesis of nanoparticles comprising metal(III)vanadate
6. Security printing liquid and method using nanoparticles
7. Paramagnetic nanoparticles
8. Synthesis of nanoparticles (Dotnan)
9. X-Ray opaque dental nanomaterials
10. Postsynthetic polyacid/base modification of nanoparticles
11. InP nanoparticles and method for their manufacture
12. Reactor for the synthesis of nanoparticles CANdots Series A
13. …

CANdots Series X


Business Model:
Contract Research
First Contact
• Discussion on ideas / problems / requests
• Non Disclosure Agreement (NDA)

Concept
Agreement on:
• R&D goals
• Timeframe
• Budget
• Patent- and License issues
• Other partners
• Legal issues

Contracts
• Small jobs (< 10 T€)
• Feasibility Studies (< 50 T€)
• R&D Contracts (> 50 T€)


Business Model:
Service
Consulting and Service
• Studies
• Surveys

CAN-Analytics
• Scanning Electron Microscopy (SEM / TEM)
• Static and Dynamic Light Scattering (SLS / DLS)
• X-Rax Scattering (SAXS / WAXS)
• Atomic Force Microscopy (AFM)
• Infrared Spectroscopy
• Mass-Spectrometry (MS, MALDI-MS)
• Absorption Spectroscopy (UV-Vis, NIR)
• Fluorescence Optical Microscopy
• Confocal Laser-Scanning Microscopy
• Electron Spin Resonance-Spectroscopy
• SQUID Magnetometry
• Chromatography
• Rheology


CAN GmbH:
Partner

University of Hamburg
Cooperation Contracts

Companies:
Beiersdorf AG www.beiersdorf.com
Eppendorf AG www.eppendorf.com
BODE Chemie GmbH www.bode-chemie.de
Merck KGaA www.merck.de
Bayer AG www.bayer.de

Institutions:
Free and Hansestadt Hamburg http://fhh.hamburg.de/
Hamburger Sparkasse www.haspa.de
Hamburg Chamber of Commerce www.hk24.de
Innovationsstiftung Hamburg www.innovationsstiftung.de
Life Science Agentur Norgenta www.norgenta.de
Center of Competence Hansenanotec www.nanoscience.de/hansenanotec/


CAN GmbH:
… get in contact !

Grindelallee 117
20146 Hamburg
Germany
T +49 40 42838 – 4983
F +49 40 42838 – 5797
E fso@can-hamburg.de

www.can-hamburg.de


Presentation of Can

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