The document discusses the governance challenges of international cooperation in science, technology, and innovation (STI) to address global issues such as climate change, health, and food security, emphasizing the systemic interconnections between these challenges. It highlights the necessity for collaborative efforts across multiple countries and sectors while pointing out the lack of comprehensive governance frameworks and funding mechanisms. Recommendations include focusing on socio-cultural contexts, flexibility in governance approaches, and integrating STI into broader policy agendas to enhance effectiveness and capacity building.