This document discusses the Global Burden of Disease study conducted by the Institute for Health Metrics and Evaluation. The study analyzes big data on global health to quantify the comparative magnitude of health loss from diseases, injuries, and risk factors by location, age, sex, and over time. It involved collaboration with hundreds of individuals from over 50 countries. The 2012 study, published in The Lancet, analyzed data from 187 countries for 1990, 2005, and 2010 on 291 causes of death, 66 risk factors, and key health metrics.