This document discusses using machine learning to help develop subgrid parameterizations for climate models based on high-resolution simulations. It notes that while high-resolution models have progressed faster than parameterizations, humans still develop parameterizations, which is slow. The document explores using machine learning on comprehensive training datasets from high-resolution models to relate coarse-grid variables to subgrid-scale quantities needed by climate models. Challenges include making schemes stochastic, handling data outside the training range, and instability in global models. Past work applying neural networks to a cloud-resolving model dataset showed promise but has not been used prognostically. Overall, machine learning may help break the parameterization bottleneck if technical challenges can be overcome.