An estimator in statistics is a rule used to calculate an estimate of a quantity based on observed data, with point estimators providing a single value and interval estimators offering a range. For an estimator to be considered Best Linear Unbiased Estimator (BLUE), it must be linear, unbiased, and efficient with the least variance. Key properties include linearity, unbiasedness, and minimum variance, ensuring the estimator's mean aligns with the true population mean.