Research in Bioinformatics
- 1. BIRLA INSTITUTE OF TECHNOLOGY,MESRA JAIPUR CAMPUS “RESEARCH IN BIOINFORMATICS” Presented By: Apoorva Nagar MCA/25013/18
- 2. BIOINFORMATICS • Bioinformatics is the science of developing computer databases and algorithms for the purpose of speeding up and enhancing biological research. • Bioinformatics is the field of science in which biology, computer science, and Information Technology (IT) merges into a single discipline. • The ultimate goal is to enable the discovery of new biological insights and to create a global perspective from which unifying principles in biology can be distinguished.
- 3. INDIAN SCENARIO • The Bioinformatics sector in India have grown up rapidly as IT companies have also stepped up their focus on the life sciences. • Indian Bioinformatics companies look forward to gather a large chunk of the world market for bioinformatics services such as data mining, mapping and DNA sequencing, functional genomics, proteomics and molecule design simulation. • India is also witnessing the emergence of pure-play bioinformatics companies such as Strand Genomics.
- 4. WORLD SCENARIO • The largest markets for bioinformatics include USA, Europe and Japan while emerging large markets include Australia, China and India. • A number of US based companies, like IBM, Sun Microsystems etc. are actively working towards developing IT based bioinformatics tools. • Analysis software and services are anticipated to be the fastest growing market in bioinformatics. • Pharmaceutical companies increased their expenditure focused towards bioinformatics.
- 5. BIOINFORMATICS IN PHARMA INDUSTRY Drug Development • Many potential drugs do not make it to market, and expensive time and resources are invested in molecules that will generate no revenue. • Simulation and informatics can significantly increase these by improving the efficiency of drug development, cutting costs, and improving margins. Formulation Design • Formulation is the process of mixing Ingredients in such a way as to produce a new or improved product. • With laboratory results stored in legacy systems, it takes expert company knowledge and experience to know which methods and suppliers are available, let alone to locate them quickly.
- 6. Crystallisation and Structure Determination • The crystal structure of a drug affects how easy it is to formulate, its bio-availability, and its shelf life. • Knowledge of the different possible polymorphs of a crystal can also give better patent protection for a drug. Drug Target Identification • One of the major thrusts of current bioinformatics approaches is the prediction and identification of biologically active candidates and mining and storage of related information. • Drugs are usually only developed when the particular drug target for those drugs actions have been identified and studied. • Bioinformatics allows the identification and analysis of more and more biological drug targets
- 7. Drug target validation • Bioinformatics also provides strategies and algorithm to predict new drug targets and to store and manage available drug target information. • After the discovery of “potential” drug targets, there is an inappreciable need to establish a strong association between a target and disease of interest. • Drug target validation helps to moderate the potential for failure in the clinical testing. Effective medication • Companies design drugs that satisfied the requirements of particular genetic sub-groups of the general population. • The main interest is to identify patients for whom drug efficacy can be predicted, and to reduce risk of adverse drugs effects
- 8. Targeting RNA with small molecules • While a majority of drugs is directed at targeting proteins responsible for a disease, sometimes it is not enough to suppress pathogenic processes.So RNA is influenced before protein synthesis in order to suppress them.
- 9. REFERNCE • https://link.springer.com/article/10.1007/s13721-013- 0039-5 • https://www.biopharmatrend.com/post/60-top-7-trends- in-pharmaceutical-research-in-2018-and-beyond/ • https://biointelligence.wordpress.com/2009/08/11/bioinf ormatics-in-pharma-industry/
- 10. THANK YOU!!!