Root Cause Analysis (RCA) is a process to understand the underlying causes of problems in order to prevent future issues. It involves asking "Why?" repeatedly to determine the root cause, typically requiring around 5 iterations. RCA principles include making it continuous, focusing on prevention over blame, and always searching for the root cause rather than stopping at surface explanations. Common leakage reasons for defects include requirements ambiguity, insufficient testing, and outdated test coverage. RCA stats can be used to measure quality and determine where to focus process improvements.