This document presents research on applying systemic design approaches to improve the environmental sustainability of medical treatments. It discusses hemodialysis as a case study. The research methodology involves analyzing the hemodialysis system through qualitative and quantitative assessments of products, equipment, treatment routines, and local organizations. Guidelines are developed to help stakeholders address sustainability in product design, equipment, and treatment processes. Fifteen design strategies are also defined to highlight topics across system items and stakeholders. The goal is to contribute systemic design knowledge that can lead sustainable innovation in healthcare.