Scrapie
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Scrapie is a neurodegenerative disease of sheep and goats caused by prions, which are abnormal infectious protein particles that replicate by converting normal cellular proteins into copies of themselves. It is transmitted both genetically and through contact with infected animals or contaminated environments. Affected animals may exhibit tremors, high-stepping gait, and compulsive scratching and wool-pulling. There is no treatment for scrapie. Control methods include keeping sheep and goat flocks separate, avoiding mixing of breeds, using scrapie-resistant breeds, and culling infected animals. Diagnosis is made through clinical signs as well as laboratory detection of prions in the central nervous system.
Scrapie
- 1. Dr. WAQAS NAWAZ DVM PMAS AAUR Rwp.Pakistan What is Scrapie???? * It is neuro-degenerative disaese caused by prions * Prions replicate by converting a normal cellular protein into copies of prions * Prions are non-conventional disease agents * It can confuse with Mad Cow Disease Etiology Host Species * Sheep * Goat * Rat & Mice * Monkey & Lab animals Geographical Distribution * Worldwide * More in developing countries Transmission * Well understood in sheep * Can transmit to goats if we keep them in the herd of sheep * Can transmit to already present sheeps if we keep foreign infected breed in our flock * Can be transmitted to the race during pregnancy or at the time of birth from dam through placenta or reproductive tract because Prions may be present there * Genetically transmitted or through urine of the sheep * Prions & Virions both can transmit it into the race Symptoms * 1st symptom is that the affected sheep will be apart from the flock & will be in front to lead the herd or at the end to trail the herd when the herd is driven * As the disease progress animals have high-stepping or trembling * Convulsions * Scraping body with the wall * Drink small quantities of water often * Blindness Treatment * No treatment * Not zoonotic disease Control * Keep goats & sheep in separate flocks * Don't mix foreign breeds with native ones * Use scrapie-resistant breeds to reduce risk * Cull the affected sheep Diagnosis * Clinical sign & symptoms * Laboratory test * Scrapie is usually confirmed by detecting PrPSc (prions) in CNS