Thermocouples operate based on the Seebeck effect, where the junction of two different conductors generates a voltage when subjected to a temperature gradient. The voltage is generated along the portion of the conductors experiencing a temperature change, not at the junction itself. The voltage can be approximated based on the Seebeck coefficients of the two materials and the temperatures of the hot and cold junctions. Thermocouples are suitable for temperature measurement over a large range up to 2300°C and are commonly used for industrial processes, though other sensors are better for small temperature changes.