Silk and Silicon Based Bio-Integrated Electronics - Slides
- 1. Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics Dawn John Mullassery Electrical and Computer Engineering University of British Columbia 1
- 2. The Paper John A Rogers 2
- 3. Overview • Motivation and Background • The technology • Future 3
- 4. http://www.singularitysymposium.com/moores-law.html MOORE’s LAW “The observation made in 1965 by Gordon Moore, co-founder of Intel, that the number of transistors per square inch on integrated circuits had doubled every year since the integrated circuit was invented. Moore predicted that this trend would continue for the foreseeable future.” - Webopedia 4
- 5. Bio-Integration 6th International Conference on Intelligent and Advanced Systems 2016 (ICIAS2016), ieeemy.org, http://www.computerhope.com/jargon/e/edsac.htm, 5
- 7. Existing Technology – Utah http://www.sci.utah.edu/~gk/abstracts/bisti03/, Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects - Eduardo et.al , doi: 10.3389/fneng.2014.00024 7
- 8. Electro - Corticography Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical Mapping N. Jeremy Hill et.al ; doi: 10.3791/3993 8
- 9. Two main areas! • Bio-integrated or Biocompatible electronics • Transient electronics or Bioresorbable electronics 9
- 10. Bio-Integrated Electronics • Epidermal Electronics • Non – uniform surfaces inside the body 10
- 11. Bio-Integrated Electronics - Brain 11
- 12. Bio-Integrated Electronics - Brain 12
- 14. Bio-Integrated Electronics - Cardiac Electrophysiology A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology: Jonathan Viventi, et.,al; Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo: Jonathan Viventi, et.al; 14
- 15. Bio-Integrated Electronics - Cardiac Electrophysiology A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology: Jonathan Viventi, et.,al; 15
- 17. Bio-Integrated Electronics - Spatiotemporal cardiac measurements 3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium. Lizhi Xu et.al; ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor 17
- 18. Bio-Integrated Electronics - Advantages • High resolution results • Less complicated process • Similar process can be used for epidermal electronics • Non – invasive method 18
- 19. Transient Electronics Electronic systems that dissolve, resorb, or otherwise physically disappear at programmed rates or specific triggered times. A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE 19
- 20. Thin Silicon Membranes Dissolve A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE 20
- 21. Water Soluble Silicon Silicon for Transient Electronics • Silicon Thickness - 35 nm • Dissolution Time – 10 days • Water – 0.4 ml Silicon for Regular Electronics • Silicon Thickness - 700 µm • Dissolution Time – 600 to 1000 years • Water - 8 L A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE 21
- 23. Transient Electronic Device A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE 23
- 24. A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE 24
- 25. A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE 25
- 26. A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE 26
- 27. Why a novel approach? • Biomedical Purposes • Environmental Sensors • Consumer Electronics 27
- 28. Biomedical Application – Transient Electronics A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE 28
- 29. Biomedical Application – Surgical Site Infections A Physically Transient Form of Silicon Electronics, et.al, 2012 VOL 337 SCIENCE 29
- 30. Edible and Good! Magnesium ~ 100 mg vs ~ 300 mg Silicon ~ 2 µg vs ~ 10 mg 30
- 31. Biomedical Applications • Drug Delivery • Electronic Aspirin 31
- 32. Environmental sensors & e- waste 32
- 34. Next Few Years & Future • Human body • Non – biomedical applications • Further R & D required 34
- 35. Why will this be a classic paper? • New approach to existing techniques of biomedical methods • Any form of biological surface – with minimal invasion • Not limited to biomedical 35
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