The document discusses a systemic approach to agile security through awareness of environmental anomalies, drawing inspiration from natural systems like horizontal gene transfer, bow tie processors, proactive anomaly search, and hierarchical sensemaking. It highlights the development of an artificial immune system for resilient cyber-network applications and outlines the architecture for self-organizing resilience in networks, aimed at enhancing threat detection and response capabilities. The proposed methods emphasize adaptability, innovation, and proactive strategies against evolving threats in adversarial contexts.