This document is the Software Guide for version 3.20 of the ORFEO Toolbox (OTB). OTB is a set of algorithms encapsulated in a software library developed by CNES to efficiently exploit results from methodological remote sensing research and development studies. It is implemented in C++ and based on the Insight Toolkit (ITK). The guide provides an introduction to OTB, instructions for downloading and installing it, and overviews of the system organization and essential concepts like the data processing pipeline and spatial objects.