STEM CELL THERAPY HAS A PROMISE IN PARKINSON’S DISEASE , Dr. Sharda Jain

STEM CELL THERAPY
HAS A PROMISE IN
PARKINSON’S DISEASE
DR. SHARDA JAIN
Dr. Rashmi Jain
Dr. Indu Tyagi
Dr. Jyoti Agarwal
Dr. Jyoti Bhaskar
Public contact
initiative
www.globalstemgenn.com
Dr. Prabhu Mishra

WELCOME
to fascinating world of STEM
CELL THERAPY – a Medical
Revolution

What is Parkinson’s Disease?

Parkinson’s disease (PD) is a
chronic progressive disease of the
nervous system characterized by
the cardinal features of rigidity,
bradykinesia, tremor and postural
instability.
What is Parkinson’s Disease?

In simple terms
• Parkinson’s disease is a disorder
of the brain that leads to shaking
(tremors) and difficulty in walking
movement, and co-ordinaation.
• It is one of the most common
nervous system disorders of the
elderly. Sometimes, Parkinson’s
disease occurs in younger adults,
but is rarely seen in children. It
affects both men and women .

Incidence
•In India, the crude age-adjusted
prevalence rate of Parkinson's disease
per 100,000 population is
14 in northern India,
27 in the south and
16 in the east,
363 for Parsis

How does it Happen?
Nerve cells use a brain chemical called
DOPAMINE to help control muscle
movement. Parkinson’s disease occurs when
the nerve cells in the brain that make
dopamine are slowly destroyed. Without
dopamine, the nerve cells in that part of the
brain cannot properly send messages. This
leads to the loss of muscle function. The
damage gets worse with time.

What are The Symptoms?
Symptoms may be mild at first.
For instance, the patient may have a mild
tremor or a slight feeling that one leg or
foot is stiff and dragging.

What are The Symptoms?
General symptoms include gradual
decrease in automatic movements,
constipation, swallowing difficulty,
drooling, impaired balance and
walking, mask-like facial expressions,
muscle aches and pains, rigid muscles,
tremors and stooped posture.

Clinical Presentation
• One of the clinical hallmark of parkinson’s
disease is rigidity
• Two types : cogwheel and lead pipe rigidity
• Cogwheel rigidity : jerky, ratchet like resistance
to passive movement and muscles alternative
tense and relax
• Lead pipe rigidity : no fluctuations, more
sustained resistance to passive movements.
• prolonged rigidity results in decreased range of
motion and serious complications of
contractures and postural deformity

• Akinnesia : absence of movement.
• Hypokinesia : reduced amplitude of the movement.
• Bradykinesia : slowness and difficult maintaining
movement. Movements are typically reduced in
speed, range and amplitude. Rigidity and
depression can also influence bradykinesia. It is the
most disabling symptom of PD
BRADYKINESIA

Tremor
• Parkinsomiam tremor is described as
resting tremor as it is typically present at
rest and disappears with voluntary
movement
• Manifests as pill – rolling tremor of hand
• Resting tremors may also be seen in the
forearm , jaw, or tongue
• Lower limb tremors as apparent when the
patients lies supine
• Postural tremor is seen in head and trunk
when patients tries to maintain upright
position against gravity
• COMPLETELY DIMINISH DURING SLEEPS

Increasing difficulty during
destabilizing activities like
walking, turning and
functional reach.
Extensor muscles of the trunk
demonstrate greater weakness
than flexor
Muscles, contributing to the
adoption of a flexed, stooped
posture with increased flexion
of the neck, trunk, hips, and
knees.
Postural instability.

• An abnormal stooped
posture contributes to
development of a
festinating gait,
characterized by a
progressive increase in
speed with a shortening
of stride.
Posture POSTURE

What are the other
symptoms?
Other symptoms include
anxiety,
stress,
confusion,
dementia,
depression,
fainting spells,
hallucinations and
memory loss.

Conventional Treatment
THERE IS
NO KNOWN CURE
FOR PARKINSON’S DISEASE.

MEDICAL aim to control symptoms, mostly
by increasing the levels of dopamine in the
brain. At certain points during the day, the
helpful effects of the medication often wears
off, and symptoms can return . Eventually,
symptoms such as stooped posture, frozen
movements, and speech difficulties may not
respond very well to drug treatment.

SURGERY may be an option for
patients with very severe Parkinson’s
disease who no longer respond to
medication.
These surgeries do not cure Parkinson’s,
but may help destroy symptoms and
stimulate movement.

Case study
In 2005, my mother 65 yrs old, a patient of Parkinsonism
for 20 yrs ,Underwent Brain stimulation surgery as a last
option as conventional medicines had failed to work.
The surgery failed miserably and she passed away in 4
months.
It was then that I was told that if stem cells therapy
( in research at that time) would have been available , she
would have been with me today.
The day has come – when every one will have a healthy
parent by their side.
Dr Jyoti Bhaskar

World Research with
Stem Cell Treatment
Numerous clinical trials are
going on all over the world to
explore the potential of stem
cells in parkinson’s disease.
Stem cell therapy has shown
to form dopamine producing
cells in the substantia nigra
of the brain.

• Stem cell therapy is helpful in patients
not responding to conventional
treatment.
• Stem cell therapy - does improve the
quality of life and helps getting rid of
most of the manifestations of
Parkinson’s disease.
World Research with
Stem Cell Treatment

Stem cell therapy improves the
quality of life.
However the response
Varies from patient
to patient
WORLD RESEARCH ON PARKINSONISM
WITH STEM CELL THERAPY

WORLD RESEARCH ON
PARKINSONISM
With STEM CELL THERAPY
We use
autologous
Bone Marrow
mononuclear
stem cells
intrathecally

Our USP
• World class clinicians and experts from
Regenerative medicine.
• State of the art, in-house stem cell lab to maximize the
yield of good quality Stem Cells
• Accurate treatment protocols for “relevant disorders”
• Proven results and experience in handling complex case
• We use Autologous stem cells for Stem Cell Therapy
(Bone Marrow, Fat, Blood)

We offer
Global stemgenn makes suitable
stem cell therapy available to
the ailing patient only after
thorough scientific
deliberations and meticulous
counseling of patient & family
with experts.

• Autologous cells for homologous use
• Same setting surgery
• Minimal manipulation of cells
• Don’t promote therapeutic results
You should know
FDA – guidelines…

• This is a patient-funded clinical trial
• Stem Cell Therapy is NOT COVERED
BY INSURANCE
• Public undertakings DO ALLOW
in GUJARAT
• The cost of the therapy ranges & mainly
depends on the complexity of the case
Fees and Insurance
cover

Global stemgenn offer you stem cell
therapy using latest technology.
These stem cells could be of various types viz.
Hematopoietic (CD 34+), Mesenchymal stem
cells (MSCs) that are processed and isolated
using Good Manufacturing Practice (GMP)
and Good Lab Practice (GLP) in accordance
with AABB standards.
Our Lab USP

Our experience of
Stem cell therapy at Global Stemgenn
- It is completely safe,
Non –Toxic and totally devoid of side
effects with good probability of homing
and engraftment with the parent cell,
tissue or organ.
Patient - Safety

STEM CELL THERAPY HAS A PROMISE IN PARKINSON’S DISEASE , Dr. Sharda Jain

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…..Caring hearts, healing hands
Is our PARENT organization

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CONTACT US
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…..Caring hearts, healing
hands
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STEM CELL THERAPY HAS A PROMISE IN PARKINSON’S DISEASE , Dr. Sharda Jain

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STEM CELL THERAPY HAS A PROMISE IN PARKINSON’S DISEASE , Dr. Sharda Jain