This paper discusses the radiation interaction mechanisms of various nuclear detectors including GM tube, scintillation counter, and HPGe detector, highlighting their distinct principles and performance metrics. Four key interaction mechanisms—photoelectric effect, coherent scattering, incoherent scattering, and pair production—are examined in relation to these detectors. Additionally, the study outlines detector bias voltages, count rates, sensitivity, and efficiency, providing valuable insights for the design and application of nuclear detection technology.