This document discusses teaching integrated science to 21st century learners. It begins with an introduction of the author which is followed by sections on biology, chemistry, earth and space science, and physics lessons. These lessons incorporate topics, hands-on activities, online resources, and field trips. The document also discusses the importance of teaching science in an interdisciplinary way and preparing high school students for college or careers. It ends with advice on lesson planning, emphasizing the importance of clear objectives, inspiration, outlining lessons, hands-on activities, and sharing resources with other teachers.