This document discusses strategies for using various technology tools to differentiate instruction for science learning. It provides a list of 4 interactive tools (Froguts, Cells Alive, Google Classroom, YouTube) and describes how each supports science concepts. Strategies are outlined for using the tools to differentiate for all learners, including providing alternative access to materials and assessments. Guidelines are also suggested for promoting responsible use of interactive tools locally and globally. Each tool's benefits and limitations are reviewed, such as Froguts' realistic graphics but need for internet access.