Telomere Length as a Predictor for Longevity and Specific Mortality
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The document critically evaluates the role of telomere length as a biomarker for predicting longevity and mortality, highlighting the biological basis of telomeres and their associations with various health outcomes. While telomere length has some correlation with cardiovascular disease mortality, it is not a strong predictor of all-cause mortality compared to other biomarkers. The findings suggest that telomere length may serve better as a complement to existing aging biomarkers and emphasize the need for collaborative research between biological and social scientists.
![1. Biology
3
Pubmed search for Telomere [MeSH term]
retrieves 12,453 articles](https://image.slidesharecdn.com/16telomeremainzrehkopf-160830211830/85/Telomere-Length-as-a-Predictor-for-Longevity-and-Specific-Mortality-3-320.jpg)
Telomere Length as a Predictor for Longevity and Specific Mortality
- 1. Telomere Length as a Predictor for Longevity and Specific Mortality: A Critical Appraisal of the State of Knowledge Biomarkers for Demographic Research 1st European meeting of the Biomarker Network August 31, 2016 David H. Rehkopf
- 2. Overview ① Biology ② Evidence for Associations with Mortality ③ Uses for Biodemography ④ Implementation 2
- 3. 1. Biology 3 Pubmed search for Telomere [MeSH term] retrieves 12,453 articles
- 4. Why Telomeres? As mechanism underlying the aging process As a specific biological indicator of physiological disregulation well prior to mortality As fundamental discovery about biology with potential health consequences 4
- 5. 2. Evidence for Association of Telomere Length with Mortality 5
- 6. Pooled relative risk of coronary heart disease 1.54 (1.30-1.83) comparing shortest third of population to longest third of population on leukocyte telomere length. Among those controlling for most confounders: 1.34 (1.04-1.74) 6
- 7. Identification of 7 loci effecting mean telomere length. Codd at al. Nature Genetics 2013. 7
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- 11. n=3,091, events=870 deaths, 9.5 years follow-up 11
- 12. In adjusted models, hazard ratios for shortest quartile: All-cause 1.2 (1.0-1.5) Cardiovascular 0.9 (0.5-1.5) Cancer 1.2 (0.7-1.9) Other 1.5 (1.0-2.1) 12
- 13. 3. Uses of Telomere length 13 Rehkopf, Needham, Lin et al. under review
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- 15. 15 Rehkopf, Dow, Rosero Bixby et al. 2013
- 16. 4. Implementation A. Tissue + cell type specific B. DNA storage time C. Seasonality D. Genetics 16
- 17. A. Tissue + cell type specific 17
- 18. B. DNA storage time (preliminary) 18 .6.811.21.4 T/Sratio(logscale) 0 10 20 30 Individuals Assay year: 2010 2014 Correction Correction of 2010 measurement: .345 3.0846 ^ T/S
- 19. C. Seasonality Difference in telomere length between those 60-74 years old and those 95+: 321 base pairs Difference in telomere length between blood collected in May and November: 200 base pairs 19
- 20. D. Genetics 20
- 21. Conclusions 1. For leukocyte telomere length, not a strong predictor of mortality, in particular much weaker than many other measures for short-term mortality. Evidence strongest for cardiovascular disease mortality. 2. Most potentially useful as 1) complement to other biomarkers of aging, 2) to capture biological age earlier in the life course 3. Continued collaborations between biological scientists and social scientists on technical issues for implementation in large population based samples 21
- 22. Acknowledgements 22 Georgetown University Dana Glei Stanford University Rita Hamad University of California, Berkeley William Dow Luis Rosero Bixby University of California, San Francisco Jue Lin Elissa Epel Elizabeth Blackburn University of Michigan Belinda Needham Funding National Institute on Aging K01 AG047280