The HTML5 WebSocket API allows for true full-duplex communication between a client and server. It uses the WebSocket protocol which provides a standardized way for the client to "upgrade" an HTTP connection to a WebSocket connection, allowing for messages to be sent in either direction at any time with very little overhead. This enables real-time applications that were previously difficult to achieve with traditional HTTP requests. Common server implementations include Kaazing WebSocket Gateway, Jetty, and Node.js. The JavaScript API provides an easy way for clients to connect, send, and receive messages via a WebSocket connection.