The document discusses reasons why smart and experienced leaders sometimes make bad decisions. It examines research in neuroscience and psychology to understand decision-making. Four main reasons are provided: 1) Overreliance on past experience that does not fit the current situation. 2) Unconscious self-interest that is not recognized. 3) Making prejudgments early on and sticking to them despite new information. 4) Attachments to people, places, or things that cloud objectivity. To reduce bad decisions, leaders must recognize their own biases, get different perspectives by bringing in opposing views, and have boards that engage in real debate rather than just agreeing.