Vindice seeks revenge against the Duke for poisoning his lover. In Act 1, it is revealed that the Duchess's youngest son raped Lord Antonio's wife. At a trial, the judges defer judgment on the youngest son and he is imprisoned, while various characters plot their own schemes of revenge, manipulation, and ambition against each other. Vindice disguises himself to infiltrate the Duke's court along with Hippolito in order to enact his revenge, while other plots and counterplots emerge.