Dr Ling Sien Ngan Anti Aging, Aesthetic  Medical Practitioner
Theories of Ageing Edith Cowan University Faculty of Communications, Health & Science Post Graduate Study in  Andrology & Men’s Health Ee 5 December 2004
Every single day, as we age , more and more people are dying of cancer, or simply of old age
Are you doing something about it?
Lowel Anti Aging + Aesthetic Clinic , SS2 ,PJ
Mission:   to enhance QoL  through comprehensive & integrated anti aging & aesthetic healthcare services.
Anti Aging  & Aesthetic   medical  practitioner   1. Anti Aging  medicine 2. Men’s health & Andrology 5. Cosmetic  surgery 4. Cosmetic  Dermatology 3. Holistic  complimentary  medicine Aesthetic / External  Anti aging
1)  Anti aging  medicine Balanced diet Nutritional supplementations + antioxidants Detoxification    ( chelation, colon hydrotherapy, FIR sauna, ozoniser okamizu Correct, moderate exercise. Weight management Syndrome X + Mx of chronic deg dse -CDD Osteoporosis Bio –identical hormones Occupational health    noise , chemical Stress Mx: relaxation    meditation , yoga Chemoprevention & cancer
vs Wellness Industry Sickness Industry Anti Aging Medicine is   Even here can still anti age !
Visible  Oxidation damage  in action Free radical damage/oxidative stress, same process causing: -Iron to  rust - Cut apple  turning brown -Underlying initiator of diseases,  e.g.: Pigmentation, wrinkle    repairable by cream CAD Multiple sclerosis Cancer Alzheimer’s dementia Stroke Macular degeneration
Theories of Ageing Biologic, epidemiologic, + demographic data – an attempt to identify a cause or process; Ageing: an extremely complex, multifactorial process; Different theories not mutually exclusive; Definition of ageing: open to various interpretations.
Summary of Presentation Life span and Life expectancy. Definition of Ageing. What causes ageing? Clinical approach to ageing.
Theories of Ageing Life span and Life expectancy. Definition of Ageing. What causes ageing? Clinical approach to ageing.
Life Span Maximum life span is the theoretic species specific, longest duration of life, excluding premature unnatural life. Jeanne Calment, died July 1997 at age of 122. Lowland gorilla: 47 yrs Horse: 35 yrs American hookworm: 15 yrs Earthworm: 6 yrs
Life Expectancy Life expectancy is the average number of additional years expected for a member of a population, regardless of cause of death.
Theories of Ageing Life span and Life expectancy.   Definition of Ageing. What causes ageing? Clinical approach to ageing.
What is Ageing?
Ageing vs Senescence “ Senescence”: deteriorative processes that constitute natural causes of death. “ Ageing”: processes of accruing maturity with the passage of time, including... George Martin. In: The ageing process, 1984
Ageing vs Senescence Positive aspects like: - becoming wiser - mellow - evolution of life style … “ just like wine, improves as it ages but not as it senesces”.
Stages of Lifespan Prenatal life Birth Postnatal life neonatal infancy childhood early middle late adolescence adulthood senescence Death fertilisation-10months birth thru’week 2 3 wks - 1st birthday 2 - 6 yrs 7 - 10 yrs prepubertal 6 yrs following puberty 20 - 65 yrs from 65 yrs Ee
What is Ageing? A ubiquitous biologic process, characterised by a progressive, inevitable evolution and maturation until death. Ee Susan A Gaylord, Mark E Williams. In: Geriatrics Review Syllabus, 1990
Theories of Ageing Life span and Life expectancy. Definition of Ageing. What causes ageing? Clinical approach to ageing. Ee
Ageing Process   primary ageing secondary ageing Ee True primary ageing is an ongoing normal process.
Environmental hazards Ionising radiation? Pollutants? Chemicals Diet? Ambient temperature? Diseases? Ee
Theories of Ageing “ The scientific study of ageing has been an odd mixture of the accumulation of mountains of dismal evidence that shows that almost anything you can think of goes wrong with age, and proposals of simplistic theories that try to explain ageing in terms of single processes, ranging from defective testicles to shortened telomeres.” Ee Brian Charlesworth, an evolutionary biologist
Theories of Ageing Research in ageing: Traditional gerontologist Evolutionary biologist 300 over theories till date! Ee
Theories of Ageing “ Programmed” theories – the biological clocks. “ Error” theories – identify environmental insults. Ee
Theories of Ageing Evolutionary Molecular Cellular Systemic Ee Brian T. Weinert and Poala S. Timiras . Theories of Ageing.  J Appl Physiol 95: 1706-1716, 2003.
Evolutionary Theories of Ageing Mutation accumulation Disposable soma Antagonistic pleiotropy Ee
Molecular Theories of Ageing Gene regulation Codon restriction Error catastrophe Somatic mutation Dysdifferentiation Ee
Cellular Theories of Ageing Cellular senescence – Telomere theory Free radical Wear-and-tear Apoptosis Ee
System Theories of Ageing Neuroendocrine Immunologic Rate-of-living Ee
Theories of Ageing Biological theories genotropic environmental Psycho-social theories: Disengagement  Exchange  Labelling Social Stratification Political economy Continuity Ee
Summary of Presentation Life span and Life expectancy. Definition of Ageing. What causes ageing? Clinical approach to ageing. Ee
Clinical Approach to Ageing Ee True ageing vs disease states Biologic ageing vs chronologic ageing Promoting positive ageing
Positive Ageing: Pre-requisites Ageing is not denied; Perceptions and understanding of ageing are not disempowering; Differences between people are acknowledged. Ee Mary Davies
Reconceptualisation  of  Ageing? Ageing exclusively characterised by declines in function & in health? Substantial heterogeneity? Existence of positive trajectories of ageing? Possible avoidance of age-related diseases and disabilities? Ee
Mechanisms of successful ageing Persistence of normal function and plasticity Compensatory responses to restore function  Interventions to replace deficient function Changing of health outcome by modifying risk profiles Prevention of diseases Strengthening of social interactions and support Ee Brian T. Weinert and Poala S. Timiras .
Promote Positive Ageing Acceptance of ageing empowerment individuality physical activity social contact/friendship developing coping skills valuing experience, knowledge etc. Denial of ageing disempowerment being stereotyped sedentary lifestyle social withdrawal psychological stress overvaluing paid work Ee Brendan Kennelly Encourage Avoid
Conclusion Ageing process is multifactorial and complex; Research is still ongoing to determine the cause(s) or explain the process of ageing; None is conclusive; One important goal: how does intervention signals the body to delay ageing? “ Successful” ageing is possible. Ee
Reading List Brian T. Weinert and Poala S. Timiras . Theories of Ageing. J Appl Physiol 95: 1706-1716, 2003. Ageing: A natural history; 1995, RE Ricklefs, CE Finch (WH Freeman & Co). Evolutionary biology of aging; 1991, MR Rose (New York: Oxford University Press).  The Aging Process: therapeutic implications; 1984, RN Butler, AG Bearn (Raven Press). Geriatrics Review Syllabus: A core curriculum;1989, JC Beck (American Geriatrics Society). Aging as a biological phenomenon: Review in Clinical Gerontology, Vol 1, No. 1, 1991. Ee
How to choose  Miss universe  supplements ?  GMP  --Supp manufacturing : poorly regulated  --Pharm factory  adherence > food factory   pharm grade OTC sure better Label, full disclosure + address --Contain actual amount stated
Choose  Ms universe supplement Where products marketed ? --Only locally in USA , < stringent --To Canada, Australia, Europe > stringent    send on-site inspection regularly --3 rd  party certification on Quality of manufacturing QC testing ( dissolvability ) --3/9 prenatal Vit ever dissolved – Uni of marryland
Antioxidant help good cell Side effect of chemo, radio = oxidative stress to normal cell Taking ^ dose antioxidant    ^ defense of normal cell while on chemo  while chemo work at peak, side effect @ minimal---   win-win Cancer cell receive double whammy Oxidative stress from antioxidant (now pro-oxidant) Chemo stress
Vit E Co Q10 B-carotene + vit A Against damage by chemo to  lung, liver, kidney, heart, skin Against damage by  Adriamycin to heart < side effect of  chemo + radio Rx All these antioxidant   protect  against damage to DNA of normal cell    From chemo + Radio Rx
INTERNAL   BEAUTY CARE
If ageing can be halted... Ee The Lost Horizon Would you choose to be in it?
SEEKING   A GOOD LIFE STYLE ? Physically and emotionally strong Age gracefully Feel good factor
 
Be all that you are   Show it off   VIBRANT  RADIANT VITALITY  Thank you
My contact E mail;  [email_address] Web;  www.aestheticandyou.com You tube; www.youtube.com/lowelantiaging Face book; www.facebook.com/drdavidling

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Theories of aging, a nti aging

  • 1. Dr Ling Sien Ngan Anti Aging, Aesthetic Medical Practitioner
  • 2. Theories of Ageing Edith Cowan University Faculty of Communications, Health & Science Post Graduate Study in Andrology & Men’s Health Ee 5 December 2004
  • 3. Every single day, as we age , more and more people are dying of cancer, or simply of old age
  • 4. Are you doing something about it?
  • 5. Lowel Anti Aging + Aesthetic Clinic , SS2 ,PJ
  • 6. Mission: to enhance QoL through comprehensive & integrated anti aging & aesthetic healthcare services.
  • 7. Anti Aging & Aesthetic medical practitioner 1. Anti Aging medicine 2. Men’s health & Andrology 5. Cosmetic surgery 4. Cosmetic Dermatology 3. Holistic complimentary medicine Aesthetic / External Anti aging
  • 8. 1) Anti aging medicine Balanced diet Nutritional supplementations + antioxidants Detoxification  ( chelation, colon hydrotherapy, FIR sauna, ozoniser okamizu Correct, moderate exercise. Weight management Syndrome X + Mx of chronic deg dse -CDD Osteoporosis Bio –identical hormones Occupational health  noise , chemical Stress Mx: relaxation  meditation , yoga Chemoprevention & cancer
  • 9. vs Wellness Industry Sickness Industry Anti Aging Medicine is Even here can still anti age !
  • 10. Visible Oxidation damage in action Free radical damage/oxidative stress, same process causing: -Iron to rust - Cut apple turning brown -Underlying initiator of diseases, e.g.: Pigmentation, wrinkle   repairable by cream CAD Multiple sclerosis Cancer Alzheimer’s dementia Stroke Macular degeneration
  • 11. Theories of Ageing Biologic, epidemiologic, + demographic data – an attempt to identify a cause or process; Ageing: an extremely complex, multifactorial process; Different theories not mutually exclusive; Definition of ageing: open to various interpretations.
  • 12. Summary of Presentation Life span and Life expectancy. Definition of Ageing. What causes ageing? Clinical approach to ageing.
  • 13. Theories of Ageing Life span and Life expectancy. Definition of Ageing. What causes ageing? Clinical approach to ageing.
  • 14. Life Span Maximum life span is the theoretic species specific, longest duration of life, excluding premature unnatural life. Jeanne Calment, died July 1997 at age of 122. Lowland gorilla: 47 yrs Horse: 35 yrs American hookworm: 15 yrs Earthworm: 6 yrs
  • 15. Life Expectancy Life expectancy is the average number of additional years expected for a member of a population, regardless of cause of death.
  • 16. Theories of Ageing Life span and Life expectancy. Definition of Ageing. What causes ageing? Clinical approach to ageing.
  • 18. Ageing vs Senescence “ Senescence”: deteriorative processes that constitute natural causes of death. “ Ageing”: processes of accruing maturity with the passage of time, including... George Martin. In: The ageing process, 1984
  • 19. Ageing vs Senescence Positive aspects like: - becoming wiser - mellow - evolution of life style … “ just like wine, improves as it ages but not as it senesces”.
  • 20. Stages of Lifespan Prenatal life Birth Postnatal life neonatal infancy childhood early middle late adolescence adulthood senescence Death fertilisation-10months birth thru’week 2 3 wks - 1st birthday 2 - 6 yrs 7 - 10 yrs prepubertal 6 yrs following puberty 20 - 65 yrs from 65 yrs Ee
  • 21. What is Ageing? A ubiquitous biologic process, characterised by a progressive, inevitable evolution and maturation until death. Ee Susan A Gaylord, Mark E Williams. In: Geriatrics Review Syllabus, 1990
  • 22. Theories of Ageing Life span and Life expectancy. Definition of Ageing. What causes ageing? Clinical approach to ageing. Ee
  • 23. Ageing Process primary ageing secondary ageing Ee True primary ageing is an ongoing normal process.
  • 24. Environmental hazards Ionising radiation? Pollutants? Chemicals Diet? Ambient temperature? Diseases? Ee
  • 25. Theories of Ageing “ The scientific study of ageing has been an odd mixture of the accumulation of mountains of dismal evidence that shows that almost anything you can think of goes wrong with age, and proposals of simplistic theories that try to explain ageing in terms of single processes, ranging from defective testicles to shortened telomeres.” Ee Brian Charlesworth, an evolutionary biologist
  • 26. Theories of Ageing Research in ageing: Traditional gerontologist Evolutionary biologist 300 over theories till date! Ee
  • 27. Theories of Ageing “ Programmed” theories – the biological clocks. “ Error” theories – identify environmental insults. Ee
  • 28. Theories of Ageing Evolutionary Molecular Cellular Systemic Ee Brian T. Weinert and Poala S. Timiras . Theories of Ageing. J Appl Physiol 95: 1706-1716, 2003.
  • 29. Evolutionary Theories of Ageing Mutation accumulation Disposable soma Antagonistic pleiotropy Ee
  • 30. Molecular Theories of Ageing Gene regulation Codon restriction Error catastrophe Somatic mutation Dysdifferentiation Ee
  • 31. Cellular Theories of Ageing Cellular senescence – Telomere theory Free radical Wear-and-tear Apoptosis Ee
  • 32. System Theories of Ageing Neuroendocrine Immunologic Rate-of-living Ee
  • 33. Theories of Ageing Biological theories genotropic environmental Psycho-social theories: Disengagement Exchange Labelling Social Stratification Political economy Continuity Ee
  • 34. Summary of Presentation Life span and Life expectancy. Definition of Ageing. What causes ageing? Clinical approach to ageing. Ee
  • 35. Clinical Approach to Ageing Ee True ageing vs disease states Biologic ageing vs chronologic ageing Promoting positive ageing
  • 36. Positive Ageing: Pre-requisites Ageing is not denied; Perceptions and understanding of ageing are not disempowering; Differences between people are acknowledged. Ee Mary Davies
  • 37. Reconceptualisation of Ageing? Ageing exclusively characterised by declines in function & in health? Substantial heterogeneity? Existence of positive trajectories of ageing? Possible avoidance of age-related diseases and disabilities? Ee
  • 38. Mechanisms of successful ageing Persistence of normal function and plasticity Compensatory responses to restore function Interventions to replace deficient function Changing of health outcome by modifying risk profiles Prevention of diseases Strengthening of social interactions and support Ee Brian T. Weinert and Poala S. Timiras .
  • 39. Promote Positive Ageing Acceptance of ageing empowerment individuality physical activity social contact/friendship developing coping skills valuing experience, knowledge etc. Denial of ageing disempowerment being stereotyped sedentary lifestyle social withdrawal psychological stress overvaluing paid work Ee Brendan Kennelly Encourage Avoid
  • 40. Conclusion Ageing process is multifactorial and complex; Research is still ongoing to determine the cause(s) or explain the process of ageing; None is conclusive; One important goal: how does intervention signals the body to delay ageing? “ Successful” ageing is possible. Ee
  • 41. Reading List Brian T. Weinert and Poala S. Timiras . Theories of Ageing. J Appl Physiol 95: 1706-1716, 2003. Ageing: A natural history; 1995, RE Ricklefs, CE Finch (WH Freeman & Co). Evolutionary biology of aging; 1991, MR Rose (New York: Oxford University Press). The Aging Process: therapeutic implications; 1984, RN Butler, AG Bearn (Raven Press). Geriatrics Review Syllabus: A core curriculum;1989, JC Beck (American Geriatrics Society). Aging as a biological phenomenon: Review in Clinical Gerontology, Vol 1, No. 1, 1991. Ee
  • 42. How to choose Miss universe supplements ? GMP --Supp manufacturing : poorly regulated --Pharm factory adherence > food factory  pharm grade OTC sure better Label, full disclosure + address --Contain actual amount stated
  • 43. Choose Ms universe supplement Where products marketed ? --Only locally in USA , < stringent --To Canada, Australia, Europe > stringent  send on-site inspection regularly --3 rd party certification on Quality of manufacturing QC testing ( dissolvability ) --3/9 prenatal Vit ever dissolved – Uni of marryland
  • 44. Antioxidant help good cell Side effect of chemo, radio = oxidative stress to normal cell Taking ^ dose antioxidant  ^ defense of normal cell while on chemo  while chemo work at peak, side effect @ minimal---  win-win Cancer cell receive double whammy Oxidative stress from antioxidant (now pro-oxidant) Chemo stress
  • 45. Vit E Co Q10 B-carotene + vit A Against damage by chemo to lung, liver, kidney, heart, skin Against damage by Adriamycin to heart < side effect of chemo + radio Rx All these antioxidant  protect against damage to DNA of normal cell  From chemo + Radio Rx
  • 46. INTERNAL BEAUTY CARE
  • 47. If ageing can be halted... Ee The Lost Horizon Would you choose to be in it?
  • 48. SEEKING A GOOD LIFE STYLE ? Physically and emotionally strong Age gracefully Feel good factor
  • 49.  
  • 50. Be all that you are Show it off VIBRANT RADIANT VITALITY Thank you
  • 51. My contact E mail; [email_address] Web; www.aestheticandyou.com You tube; www.youtube.com/lowelantiaging Face book; www.facebook.com/drdavidling

Editor's Notes

  • #47: More Asians than ever are rediscovering themselves through SCIENCE-BASED AESTHETIC PROCEDURES and PLASTIC SURGERY.