The UiPath 2021.4 release includes notable enhancements in UiPath Studio, such as an improved installation wizard, new features for error display, and modern user interface options, allowing for easier coding and maintainability. The release also emphasizes user experience in UiPath Assistant and Robot, introducing widgets and improved process management for automation efficiency. Finally, UiPath Orchestrator now supports multiple entry points in processes and enhanced role management for better resource sharing and permissions control.