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Toxoplasmosis
Fredy RS Gutierrez MD, MSc, PhD
Objetivos de aprendizaje
• Describir los aspectos epidemiológicos de la
infección humana por T. Gondii
• Describir los aspectos fisiopatológicos
• Identificar medidas de prevención
Toxoplasma gondii ciclo
Guerrant Tropical Infectious diseases 3rd Ed 2011
Toxoplasma gondii
• Protozoario intracelular
• Altamente prevalente en el mundo
• Genotipos I al III
• Cuadros clínicos diversos
– Corioretinitis
– Congénita
– Transplantados
– Inmunosuprimidos
• Receptors que median invaison: laminina, lectina,
(SAG1)
Nat Struct Biol 9 (8): 606–11. doi:10.1038/nsb819
T. gondii
Nature Reviews Immunology Feb 2014 doi:10.1038/nri3598
T. Gondii
Formas
T. gondii
PLoS Pathog 9(12): e1003779.
doi:10.1371/journal.ppat.1003779
Respuesta innata
Nature Reviews Immunology Feb 2014 doi:10.1038/nri3598
T gondii
Mandell and Benett PPID 7th Ed 2010
T gondii
Mandell and Benett PPID 7th Ed 2010
Encefalitis por Toxoplasma
Cohen Infectious diseases 3rd Ed 2010
Toxoplasmosis gestacional
Cohen Infectious diseases 3rd Ed 2010
T gondii
Mandell and Benett PPID 7th Ed 2010
Bauman Microbiology with diseases by body systems 4th Ed 2010
T. gondii
Corioretinitis
Cohen Infectious diseases 3rd Ed 2010
T. gondii
Corioretinitis
Mandell and Benett PPID 7th Ed 2010
T gondii
Corioretinitis
Mandell and Benett PPID 7th Ed 2010
T gondii
Corioretinitis
Mandell and Benett PPID 7th Ed 2010
T gondii
Mandell and Benett PPID 7th Ed 2010
T gondii
Mandell and Benett PPID 7th Ed 2010
Guerrant Tropical Infectious diseases 3rd Ed 2011
T gondii
Mandell and Benett PPID 7th Ed 2010
T gondii
Mandell and Benett PPID 7th Ed 2010
T gondii
Mandell and Benett PPID 7th Ed 2010
Tratamiento
Mandell and Benett PPID 7th Ed 2010
Prevención
Mandell and Benett PPID 7th Ed 2010
Toxoplasmosis congénita
Frecuencia de transmisión vertical
Mandell and Benett PPID 7th Ed 2010
Lecturas sugeridas
• Mandel infectious diseases 7ª Ed. Cap 279
• Tortora Microbiology 11th Ed.
• Murray Microbiologia Médica 6ª Ed. Cap 82.

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Toxoplasmosis