This white paper discusses best practices for human resources management in an uncertain economy based on interviews with two CEOs. They advise focusing on hiring the right talent, including those with an entrepreneurial spirit and strong cultural fit. When layoffs are necessary, companies should cut boldly while treating employees fairly. Successful companies retain employees by keeping them challenged and invested in the company's success. Benefits should meet the diverse needs of the workforce as a company's demographics change over time. Overall, adhering to best practices in HR management can help companies succeed, even during economic uncertainty.