Using side effects for drug target identification
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The document discusses using drug side effects to identify new drug targets. It describes how analyzing the similarity between side effect profiles of different drugs can reveal shared targets, even for drugs that are chemically dissimilar. The author and others developed databases of drug side effect information from package inserts and text mining. They used this information to build a drug-drug network and test predictions, finding binding or activity for the majority of drug pairs examined. Future work involves better linking side effects to specific targets and direct target prediction.
Using side effects for drug target identification
- 1. Using side effects for drug target identification Lars Juhl Jensen
- 2. the problem
- 3. new uses for old drugs
- 7. Campillos & Kuhn et al., Science, 2008
- 8. Campillos & Kuhn et al., Science, 2008
- 9. similar drugs share targets
- 11. the idea
- 14. drug treatment
- 15. side effects
- 16. the hard work
- 17. information on side effects
- 18. no database
- 19. package inserts
- 20. Campillos & Kuhn et al., Science, 2008
- 21. text mining
- 23. backtracking
- 24. Campillos & Kuhn et al., Science, 2008
- 26. SIDER Kuhn et al., Molecular Systems Biology, 2010
- 28. Campillos & Kuhn et al., Science, 2008
- 29. GSC weighting
- 31. Campillos & Kuhn et al., Science, 2008
- 33. Campillos & Kuhn et al., Science, 2008
- 34. p-values
- 35. Campillos & Kuhn et al., Science, 2008
- 38. Campillos & Kuhn et al., Science, 2008
- 40. reference set
- 42. text mining
- 44. MATADOR Günther et al., Nucleic Acids Research, 2008
- 45. Campillos & Kuhn et al., Science, 2008
- 46. text mining
- 47. Reflect.ws
- 48. Pafilis, O’Donoghue, Jensen et al., Nature Biotechnology, 2009
- 51. the results
- 53. Campillos & Kuhn et al., Science, 2008
- 54. categorization
- 55. Campillos & Kuhn et al., Science, 2008
- 57. in vitro binding assays
- 58. Ki<10 µM for 11 of 20
- 59. cell assays
- 60. 9 of 9 showed activity
- 61. the future
- 62. link side-effects to targets
- 64. Acknowledgments Side effects – Monica Campillos – Michael Kuhn – Anne-Claude Gavin – Peer Bork Reflect.ws – Heiko Horn – Sune Frankild – Evangelos Pafilis – Reinhardt Schneider – Sean O’Donoghue
- 65. larsjuhljensen