Protein networks: A basis for large-scale data mining

The document discusses protein interaction networks and their use as a basis for large-scale data mining. It describes three phases: 1) building association networks using computational predictions, experimental data and curated knowledge, 2) constructing signaling networks using phosphoproteomics data to map signaling events, and 3) developing dynamic networks to study temporal protein interactions and cell cycle regulation using time course microarray data. The networks integrate different data sources to generate specific predictions and provide insights into systems properties and evolutionary flexibility.