This document outlines core components for infection prevention and control (IPC) programs at both the healthcare facility and national levels. It recommends establishing IPC programs with dedicated staff and resources, developing evidence-based guidelines, providing IPC education and training, conducting HAI surveillance, and implementing multimodal strategies using a combination of interventions to improve IPC practices and reduce healthcare-associated infections and antimicrobial resistance. The core components provide guidance on setting up the organizational structures, key activities, and linkages needed for effective IPC programs.