Work Term #1
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1) The document summarizes work completed on deformable registration techniques and quality assurance (QA) processes during a work term. 2) For deformable registration, a phantom study was conducted to evaluate an open source registration algorithm, with results showing good agreement between reference and deformed contours. 3) For QA, a software called QATrack+ was developed to streamline daily, weekly, and monthly machine QA, storing results in a centralized database for easy review and trending of data. Future work is outlined to automate processes and improve customization and review of QA data.
![1. Defining Control Points
STANESCU, Teodor et al. Investigation of a 3D system distortion correction method for MR images. Journal of Applied Clinical Medical Physics, [S.l.], v. 11, n. 1, jan. 2010.
ISSN 15269914. Available at: <http://www.jacmp.org/index.php/jacmp/article/view/2961/1799>. Date accessed: 01 May. 2014. doi:10.1120/jacmp.v11i1.2961.](https://image.slidesharecdn.com/7fb4146a-0dc3-4441-8227-6e352ff923ae-150528214845-lva1-app6892/85/Work-Term-1-13-320.jpg)
Work Term #1
- 1. Work Term #1 Summary of objectives and completed work Matthew Strugari May 2, 2014
- 2. Outline • Background • Workflow • Calculations • Results • Future Work Prostate Deformable Registration • Background • QATrack+ • Results • Future Work Quality Assurance
- 4. Deformable Registration A method of mapping two or more imaging data sets Endo-rectal coil Endo-rectal coil Prostate Prostate Bladder
- 5. Deformable Registration • Development and validation of an open source deformable registration technique for efficient integration of MR imaging into radiation treatment planning Synopsis • To develop a phantom based method to evaluate the efficacy of an established deformable image registration technique Goal
- 6. CIRS Multi-Modality Imaging Phantom Fixed Image Moving Image Water BagsWater Bags Prostate Endo- Rectal Coil Urethra Axial Slice
- 7. CIRS Multi-Modality Imaging Phantom Fixed Image Moving Image Prostate Urethra Endo-Rectal Coil Seminal Vesicles Seminal Vesicles Endo-Rectal Coil Fiducial Marker Prostate Urethra Fiducial Marker Sagittal Slice
- 8. General Workflow • Contours are created using Aria Eclipse treatment planning system • Deformable registration technique is applied using the 3D Slicer open source software • Measurements and calculations are performed directly within 3D Slicer
- 9. Contours - Prostate Fixed Image Moving Image “Eclipse”. Varian Medical Systems. 2014. 1 May 2014. <http://www.varian.com/us/oncology/radiation_oncology/eclipse/>. Axial Slice
- 11. 3D Slicer Workflow Full Image Cropped Image
- 13. 1. Defining Control Points STANESCU, Teodor et al. Investigation of a 3D system distortion correction method for MR images. Journal of Applied Clinical Medical Physics, [S.l.], v. 11, n. 1, jan. 2010. ISSN 15269914. Available at: <http://www.jacmp.org/index.php/jacmp/article/view/2961/1799>. Date accessed: 01 May. 2014. doi:10.1120/jacmp.v11i1.2961.
- 14. 2. Computing the B-Spline Functions Spline Basis Spline •“Quadratic Spline”. Wikipedia. 29 Jan 2011. 1 May 2014. <http://en.wikipedia.org/wiki/File:Quadratic_spline_six_segments.svg>. •Sharp, Gregory. “Cubic B-Splines”. Deformable Image Registration Using B-Splines. 10 Feb 2011. 1 May 2014. <http://chapter.aapm.org/NE/DOCUMENTS/Presentations/2011Winter/sharp-neaapm-2011-02-10.pdf>.
- 15. 3. Computing the Deformation Field vx(u)=∑iPiBi(u) Sharp, Gregory. “Cubic B-Splines”. Deformable Image Registration Using B-Splines. 10 Feb 2011. 1 May 2014. <http://chapter.aapm.org/NE/DOCUMENTS/Presentations/2011Winter/sharp-neaapm-2011-02-10.pdf>.
- 16. 4. Evaluating the Cost Function Inflated vs. Deflated
- 17. 5. Optimization: Gradient Descent vx(u)=∑iPiBi(u) Gradient Descent Results
- 19. Results: Deformation Vector Field
- 20. Results: Deformation Vector Field
- 21. Results: Deformed Image Fixed Image Deformed Image Axial Slice
- 22. Results: Contour Deformation Fixed Prostate Deformed Prostate Fixed Urethra Fixed Seminal Vesicle Deformed Urethra Deformed Seminal Vesicle
- 23. Calculations: Dice Similarity Coefficient Urethra Seminal Vesicles Prostate
- 24. Calculations: Hausdorff Distance Metric Axial Slice Sagittal Slice “Hausdorff Distance Sample”. Wikipedia. 6 May 2008. 1 May 2014. <http://en.wikipedia.org/wiki/File:Hausdorff_distance_sample.svg>.
- 25. Calculation Results Organ Dice Similarity Coefficient Hausdorff Distance (mm) Reference Volume (cc) Deformed Volume (cc) Prostate 0.9733±0.0003 3.56±0.01 50.61 53.26±0.03 Urethra 0.917±0.001 2.40±0.10 3.265 3.529±0.009 Seminal Vesicle 0.843±0.008 3.30±0.2 2.87 2.22±0.04
- 26. Conclusion It is possible to develop a phantom based method to evaluate the efficacy of an established deformable image registration technique The results for the main anatomical regions were satisfactory
- 27. Conclusion This method can be applied to a number of different modalities such as CT, CBCT, MR, and PET Deformable registration is useful for adaptive radiotherapy to account for anatomical changes throughout a patient’s treatment
- 28. Future Work Automating the process using Plastimatch Applying this process to in vivo data sets Finite element analysis for prostate deformation using Elmer FEA
- 30. QA: Outlined by CPQR Functionality Reproducibility Accuracy “Emergency Stop”. Dreamstime. 2014. 1 May 2014. < http://www.dreamstime.com/photos-images/security-emergency-help-point.html>. “The Life Cycle of a Website”. Standing Dog. 12 Mar 2013. 1 May 2014. < http://www.standingdog.com/blog/the-life-cycle-of-a-website/>. “Accuracy and Precision”. Math is Fun. 2013. 1 May 2014. < http://www.mathsisfun.com/accuracy-precision.html>.
- 32. Machine QA CatPhan “CatPhan©504 Manual”. The Phantom Laboratory. 2013. 1 May 2014. <http://www.phantomlab.com/library/pdf/catphan504manual.pdf>. “Profiler 2”. Sun Nuclear Corporation. 2013. 1 May 2014. <http://www.sunnuclear.com/medPhys/machineqa/profiler2/profiler2.asp>. “ArcCHECK”. Sun Nuclear Coroporation. 2013. 1 May 2014. <http://www.sunnuclear.com/medPhys/patientqa/arccheck/arccheck.asp>.
- 33. Current Condition of QA Argus implemented in SCC
- 34. QATrack+
- 35. QATrack+
- 37. QATrack+ Features Trendline Reference Value Tolerance Level Action Level •Oasis Daily QA, 6 MV 10x10 output
- 38. QATrack+ Features •Oasis Daily QA: 6 MV, 10 MV, and 15 MV 10x10 output 6 MV 15 MV 10 MV
- 39. Results Two complete months of daily QA data for all machines QA data and results are kept in one location for daily, weekly, and monthly QA
- 40. Results: Oasis 6 MV Daily6 MV Monthly 10 MV Daily 10 MV Monthly 15 MV Daily 15 MV Monthly
- 41. Conclusion QATrack+ saves time, effort, and money QATrack+ meets the CNSC standards and legal requirements Records are stored to a database and are readily available QATrack+ is fully customizable Unpredictable run times due to the use of QATrack+ software on a desktop computer
- 42. Future Work Modifications/elimination of weekly QA Implementation of monthly and annual QA Transfer QATrack+ to a server Regular review QA data E-mail notifications Setup of unique user groups and user accounts
- 43. Special Thanks Saskatchewan Cancer Agency Medical Physics: Deluan Tu; Niranjan Venugopal; Andrew Alexander External: Gregory Sharp, Medical Physicist (Massachusetts General Hospital); Randle Taylor, Medical Physicist (Ottawa Hospital Cancer Centre)