This document describes Region-of-Interest Advanced Video Coding (RoI-AVC), a semantic video codec that achieves coding efficiency and complexity advantages over H.264/AVC. RoI-AVC uses a joint optimized design that bridges computer vision and video coding. It detects regions of interest using multi-scale motion detection and flexibly encodes those regions using H.264, saving up to 34% bitrate with similar quality compared to H.264. The detection is fast, reliable, and operates directly on video frames without background modeling.