Yes/no questions and wh-questions differ in form and use. Yes/no questions can be answered with a yes or no and are used to request information. They begin with an auxiliary verb like "is" or "are" before the subject. Wh-questions begin with an interrogative word like "what", "when", or "why" followed by an auxiliary verb and subject. They are also used to request information. Wh-questions can include question phrases with "what" or "how" to ask for specific details like times, colors, frequencies, or durations.