This chapter discusses age-related changes to the endocrine system and two major endocrine problems - diabetes mellitus and thyroid disease. Regarding diabetes, it covers risk factors, diagnostic criteria, goals of management including lifestyle changes and medication management, and difficulties caring for older adults with diabetes. For thyroid disorders, it describes hypothyroidism and hyperthyroidism symptoms and nursing assessments. Nursing diagnoses associated with endocrine problems depend on the individual's health status and treatment success.