Neurogear introduction 2018
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Three out of ten people suffer from mental disorders but existing medications and therapies are expensive, ineffective, and have side effects. neurogearTM is an effective alternative brain therapy that uses a headset with electromagnets to generate a targeted magnetic field for non-invasive deep brain stimulation. This focuses magnetic stimulation on specific areas of the brain to treat various mental health conditions with greater accuracy than other non-invasive methods like TMS, fewer side effects than invasive therapies, and at a lower cost.
Neurogear introduction 2018
- 2. 2 Problems of Current Mental Healthcare Three out of ten people suffer from mental disorders Mental Disorders are Common Depression ADHD Others Existing Medications & Therapies Mental Healthcare is broken Expensive Ineffective Side effects
- 3. 3 Effective Treatment for Mental Healthcare Effective Brain Therapy
- 4. 4 neurogearTM headset neurogearTM controller Magnetic Field up to 10mT (100G) High accuracy stimulation Automatic fitting Interface with touch screen Pre-configured treatment modes Designed for professional use Easy-to-Use and Intuitive Interface
- 5. 5 4-pairs of electromagnets generate a unique magnetic field. Non-Invasive Deep Brain Stimulation Increased ion concentrations (Na+, K+) in the target brain area by magnetic field focusing The magnetic field is focused on a targeted area via neurogearTM’s patented magnetic control system 01 Quadrupole Structure. 02 Magnetic Field Focusing 03 Targeted Brain Stimulation The ventral midbrain activation by Quadrupole Focusing SystemTM Unique Design and Patented Technology Powered by Quadrupole Focusing SystemTM
- 6. 6 Invasive DBS Surgery Stimulation Accuracy <0.5mm Non-Invasive neurogearTM Stimulation Accuracy <1.0 cm Stimulation Area Non-Invasive TMS Stimulation Accuracy <1.0 cm Not for Deep Brain Stimulation Stimulation Area Stimulation Area Treatment Accuracy Comparisons neurogearTM activates the target brain region with high accuracy DBS TMS
- 7. 7 Side Effects Comparisons neurogearTM is safer than other treatments Headache NO YES YES Potential Seizures NO YES YES Vertigo NO YES YES Sleep Disorders NO YES YES Surgical Procedure NO NO YES Infection NO NO YES Stroke NO NO YES TMS Invasive Surgical Treatment Fitzgerald, 2011 Vadala et al. 2015
- 8. ExpensiveLimited Treatment (Up to 2 cm from scalp, Low precision) Difficult to Operate (requires training) Various Side Effects Existing Brain Stimulation neurogearTM Scalp discomfort Headache Seizures 10% TMS neurogearNon-invasive DEEP BRAIN STIMULATION high stimulation precision (<1.0cm) Stimulation Area Affordable up to 90% of cost reduction Easy to Use Intuitive touch screen interface Effective Treatment Minimized Side Effects Stimulation Area 8
- 9. 9 Subthreshold depression is associated with impaired resting- state functional connectivity of the cognitive control network Hwang et al. Translational Psychiatry 2015 neurogearTM - Mood Mode 0 20 40 60 80 100 Week 0 Week 1 Week 2 Week 3 Week 4 Week 5 Placebo Stimulation Cognitive Control Network neurogearTM Configuration None + - Magnetic Orientation Magnetic Field • Duration: 20 min • Frequency: 10Hz • Amplitude: 10mT Target Brain Stimulation Clinical Data * Visual Analog Score ranges from 0 (no depression) to 100 (extreme depression) Martiny et al. Biol Psychiatry 2010 • The increased connectivity of the cognitive control network has been known to be correlated with reduced depression. • Mood mode configuration activates the cognitive control network, restoring balance and function to its connectivity. • Results of a five week placebo-controlled study indicate that participants that received stimulation had a significant reduction in their visual analog depression scores.
- 10. 10 neurogearTM - Creativity Mode Long-range functional connectivity between cognitive and sensory networks increases in high-creative tasks neurogearTM ConfigurationTarget Brain Stimulation Clinical Data None + - Magnetic Orientation Magnetic Field ** Duration : 20 min ** Frequency : 10Hz ** Amplitude : 10mT Beaty et al. PNAS 2018 Lustenberger et al. Cortex 2014 High connectivity in cognitive and sensory networks • High level of creativity is associated with varied connections made between distant cortexes of the brain. • The magnetic field created by neurogearTM fortifies the long-range connectivity between cognitive and sensory networks • Results of a placebo-controlled study revealed that the creativity index improved by 20% in the stimulation group compared to the placebo group. Placebo Stimulation
- 11. 11 neurogearTM - Focus Mode Prefrontal cortical activity decreases in patients with Alzheimer’s disease. neurogearTM ConfigurationTarget Brain Stimulation Clinical Data None + - Magnetic Orientation Magnetic Field • Duration : 20 min • Frequency : 10Hz • Amplitude : 10mT Yun et al. Alzheimer’s Research & Therapy 2016Yun et al. Alzheimer’s Research & Therapy 2016 Prefrontal Cortex • Activation of the prefrontal cortex is highly related to memory function and cognitive behavior improvements • Focus mode configuration activates the prefrontal cortex • After three-week stimulation, both MMQ-A & MMQ-C improved significantly only in the stimulation group. Placebo Stimulation * MMQ-A(Multifactorial Memory Questionnaire Ability) assesses memory lapses in everyday activities, MMQ-C(Contentment) measures the subjective satisfaction of patients’ memory ability and
- 12. 12 neurogearTM - Expert Mode Functional connectivity between the ventromedial prefrontal cortex (VMPFC) and ventral midbrain allows us to target deep brain region neurogearTM ConfigurationTarget Brain Stimulation Clinical Data None + - Magnetic Orientation Magnetic Field ** Duration : 20 min ** Frequency : 10Hz ** Amplitude : 10mT Yun et al. 2016Chib, Yun et al. Translational Psychiatry 2013 Ventromedial Prefrontal Cortex & Ventral Midbrain • Stimulation on VMPFC elicits remote functional changes within the ventral midbrain, which is a deep brain region involved in Parkinson’s disease. • Expert mode can be configured to create the magnetic field throughout VMPFC and midbrain area • Findings of placebo-controlled study indicate that the attractiveness ratings (related to midbrain activation) increased only in the stimulation group Example - Deep Brain Stimulation Scenario