The document provides guidance on writing a research manuscript for publication. It discusses the typical sections of a research manuscript including the title, abstract, introduction, methods, results, discussion, conclusion, acknowledgments, references, figures and tables. For each section, it provides guidelines on what to include and what not to include, with the goal of clearly communicating new scientific findings to readers. Key points covered include having a clear statement of the problem in the introduction, providing enough detail in the methods to allow replication, only presenting results in the results section, and relating the study findings to prior work in the discussion.