This document provides advice on how to be the indispensable employee that an employer will be least likely to lay off or terminate. It recommends six key strategies: 1) Know the purpose of work, which is to help the company make money; 2) Be low maintenance and flexible; 3) Be a problem solver; 4) Act like you own the business; 5) Anticipate questions your boss needs answered; and 6) Understand the economic realities of running a business and employing people. The document uses examples from veterinary practices to illustrate how to implement these strategies and assess one's own performance.