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Dr Siddhartha Sharma
Dr Siddhartha Sharma
Associate Professor,
Department of Anaesthesia,
SMS Medical College, Jaipur
1
 Mechanical Ventilation is ventilation of the
lungs by artificial means usually by a
ventilator.
ventilator.
 A ventilator delivers gas to the lungs with
either negative or positive pressure.
2
 Negative pressure ventilation
Iron lung
Chest cuirase
Chest cuirase
 Positive pressure ventilation
Invasive
Non invasive
3
1. Relieve respiratory distress
2. Decrease work of breathing
3. Improve pulmonary gas exchange
3. Improve pulmonary gas exchange
4. Reverse respiratory muscle fatigue
5. Permit lung healing
4
 Pressure
 Volume
 Flow
 Time
5
 Control -the mechanical breath goal, ie, a
set pressure or a set volume
 Trigger -Variable which starts inspiration
Trigger
Limit - the maximum permitted value during
inspiration.
 Cycle - Variable which ends inspiration
6
7
Breath types
• Mandatory breath
Ventilator does the work
Ventilator controls start and end of inspiration
• Assist control breath
patient triggers the breath
Venti. Delivers the breath as per control variable
8
Venti. Delivers the breath as per control variable
• Spontaneously Supported breath
Pt. triggers the breath
Ventilator delivers pressure support
• Spontaneous
Patient takes on work
Patient controls start and stop
18
9
Scalars are waveform representation of
pressure,flow,or volume on y axis vrs time on x axis.10
11
11
 Indications for ventilator support present
 Non-invasive v/s Invasive ventilation
 Pressure v/s Volume ventilation
 Extent (Partial v/s Full) & mode of ventilation
 Extent (Partial v/s Full) & mode of ventilation
 Key Ventilatory settings
 Appropriate Alarms and Back-up values
 Weaning
12
 Patient not breathing
 Patient breathing, …….but not enough
 Patient breathing enough, …….but
hypoxemic / hypercapneic
 Patient breathing with normal gas
 Patient breathing with normal gas
exchange, ….but working hard
 Airway protection
13
 Clinical deterioration
 Hypoxia : pO2<60mm Hg
 Hypercarbia : pCO2 > 50mm Hg
Hypercarbia : pCO2 > 50mm Hg
 Tachypnea : RR >35
 Tidal volume <3-5 ml/kg
 Max. inspiratory pressure <-20 cm H2O
14
Non
Non-
- invasive
invasive
ventilation
ventilation
ventilation
ventilation
CPAP /
CPAP /BiPAP
BiPAP
15
 Patient continuously receives a set
air pressure, during both
inspiration and expiration.
 Patient has full control over
 Patient has full control over
respiratory rate, inspiratory time ,
and depth of inspiration.
16
 This provides a set inspiratory pressure and a
different set of expiratory pressure
 Initial setting:
EPAP:5cm H2O
IPAP: 8cm H2O
O2 @ 2-5 L/min
Final IPAP pressures of 15 to 22 cm H2O are
common
17
 Patient has full control over the
respiratory rate, inspiratory time and
depth of inspiration
IPAP & EPAP can be increased by
 IPAP & EPAP can be increased by
increments of 2
 BiPAP = CPAP + Pressure support during
inspiration
18
1.Cardiogenic pulmonary edema , exacerbation
of COPD , Post-op respiratory failure.
2.Neuromuscular disease with respiratory
muscle weakness, OSA.
muscle weakness, OSA.
3.Terminally ill patients & Immuno
compromised patients.
4 Weaning mode.
19
Advantages:
1 Complications of intubation –avoided
2 Allows speech ,feeding
Disadvantages:
1.Patient should be alert with normal
1.Patient should be alert with normal
respiratory drive and intact upper airway
2 Cannot protect airway and does not
provide full 100% ventillatory support
4 Claustrofobia & uncomfortable for
patients
20
Improvement in:
1. Respiratory rate and heart rate
2. Dyspnea
2. Dyspnea
3. Oxygen requirement
4. Hypercarbia
21
 Provides all the energy for Alveolar Ventilation
 Every breath is fully supported by the ventilator
 In classic control modes, patients are unable to
breathe except at the controlled set rate
 In newer control modes, machines may act in
 In newer control modes, machines may act in
assist-control, with a minimum set rate and all
triggered breaths above that rate are also fully
supported.
 Ensures that patient is not required to do any
Work .Of.Breathing
22
When to Consider:
 Spontaneously breathing patient.
 Comfortably provide a portion of their
required minute volume
required minute volume
 Useful for weaning patients from MV support
When not to consider:
 Should be avoided in case of patients with
ventilatory muscle fatigue
23
PRESSURE VOLUME
Tidal Volume Variable Constant
Peak Ins Pressure Constant Variable
Dys-synchrony Less More likely
Barotrauma Less More likely
Flow Pattern Decreasing Preset
24
 Balance CO2 removal v/s lung protection
 If CO2 clearance more important than lung
protection, use VOLUME
If lung protection is more important than CO
 If lung protection is more important than CO2
removal use PRESSURE
 If patient triggered ventilation, synchrony
may be enhanced with PRESSURE
25
 The ventilator delivers a preset TV at a specific
R/R and inspiratory flow rate.
 It is irrespective of patients’ respiratory efforts.
 In between the ventilator delivered breaths the
inspiratory valve is closed so patient doesn’t take
additional breaths.
 PIP developed depends on lung compliance and
respiratory passage resistance.
26
27
 Ventilator gives pressure limited, time cycled
breaths thus preset inspiratory pressure is
maintained.
Decelerating flow pattern.
 Decelerating flow pattern.
 Peak airway/alveolar pressure is controlled but
TV, minute volume & alveolar volume depends
on lung compliance, airway resistance, R/R & I:E
ratio.
28
29
 Ventilator assists patient’s initiated breath, but if
not triggered, it will deliver preset TV at a preset
respiratory rate (control).
 Mandatory mechanical breaths may be either
 Mandatory mechanical breaths may be either
patient triggered (assist) or time triggered
(control)
 If R/R > preset rate, ventilator will assist,
otherwise it will control the ventilation.
30
31
 Ventilator delivers either assisted breaths at
the beginning of a spontaneous breath or time
triggered mandatory breaths.
 Synchronization window- time interval just
prior to time triggering.
prior to time triggering.
 Breath stacking is avoided as mandatory
breaths are synchronized with spontaneous
breaths.
 In between mandatory breaths patient is
allowed to take spontaneous breath at any TV.
32
33
 Patient is spontaneously breathing
 The vent augments the patient’s respiratory
effort with a “pressure support”
 Tidal Volume is determined by patient’s effort
and respiratory system compliance
Can set a FiO2 PEEP and PS above PEEP
 Can set a FiO2 PEEP and PS above PEEP
◦ Can not set respiratory rate except
back-up apnea rate.
34
 FiO2
 Tidal Volume /Pressure
 Respiratory Rate
PEEP
 PEEP
 Flow Rate
 I:E Ratio
 Trigger
35
Start with FiO2 =1.0 and titrate to SpO2
>=94%
ABG after 20-30min
Goal –PaO2 between 60 –100 mmHg
If FiO2 requirement is>0.5 , increase PEEP
FiO2 =1.0, before & after suction, during
bronchoscopy, & any other risky procedure
36
 The tidal volume is the amount of air delivered with each breath.
 Initial tidal volumes should be 8-10ml/kg, depending on
patient’s body habitus.
 If patient is in ARDS consider tidal volumes between 4 – 6
 If patient is in ARDS consider tidal volumes between 4 – 6
ml/kg with increase in PEEP
 In Pressure-Targeted modes you’ll set the Pressure High (PH)
according to the delivered tidal volume
37
 Males: IBW = 50 kg + 2.3 kg for
each inch over 5 feet.
Females: IBW = 45.5 kg + 2.3 kg
 Females: IBW = 45.5 kg + 2.3 kg
for each inch over 5 feet.
38
 An optimal method for setting the
respiratory rate has not been established.
 12 - 15/Min – Adult
20+_ 3 - Child
20+_ 3 - Child
30- 40 - New born
On some machines you set the Inspiratory
Time (Ti) and Expiratory Time (Te)
39
 Increase RR –
Hypoxia
Hypercapnoea / Resp. Acidosis
Sepsis, ARDS, metabolic acidosis
Sepsis, ARDS, metabolic acidosis
 Decrease RR-
Hypocapnoea
Resp. Alkalosis
Asthma / COPD
40
• Minute Ventilation (L/min) = RR
(b/min) x Tidal Volume (liters)
• If you decrease one or both the MV will
• If you decrease one or both the MV will
decrease resulting inHypercapnia
• Tolerated in status asthmaticus and
ARDS/ALI – Called “permissive hypercapnea”
41
 A typical initial PEEP applied is 5 cmH2O.
 Adjust up by increments of 2 for marked
hypoxia
However, up to 20 cm H2O used in ARDS
 However, up to 20 cm H2O used in ARDS
 PEEP increases intra thoracic pressure and can
thus decrease venous return and thus Blood
Pressure
42
 Improves oxygenation
Recruits Lung in ARDS
Prevents collapse of alveoli
Diminishes the work of breathing
43
 Peak flow rates of 60 L per minute
 Higher rates are frequently necessary in
Asthma or those with air hunger
 An insufficient peak flow rate is
characterized by dysnoea, spuriously low
characterized by dysnoea, spuriously low
peak inspiratory pressures, and scalloping of
the inspiratory pressure tracing
 Pressure-Targeted modes allow patient to
dictate the flow rate that they want
44
 During spontaneous breathing, the normal I:E
ratio is 1:2.
 If exhalation time is too short “breath stacking”
occurs resulting in an increase in end-expiratory
pressure also called auto-PEEP.
 Asthma/COPD 1:3, 1:4, …
 Severe hypoxia ARDS 1:1, 2:1,
45
 Most frequently used to obtain an estimate of
Plateau pressure and static compliance
 Patient should not be actively breathing
 When used with each breath, improves
distribution of air, V/Q ratio.
46
 Pressure triggering -1to -2cm H2O
Ventilator-delivered breath is initiated if the
demand valve senses a negative airway
pressure deflection greater than the trigger
sensitivity.
Flow triggering
 Flow triggering 1 to 3 L/ min (preferred)
Continuous flow of gas through the ventilator
circuit is monitored. A ventilator delivered
breath is initiated when the return flow is less
than the delivered flow
47
•different medications for sedation.
• Opiates (morphine, fentanyl)
Benzodiazepines (Midazolam)
Opiates (morphine, fentanyl)
Benzodiazepines (Midazolam)
• Propofol
• Less is sometime more
48
• Paralysis without sedation = Torture
Atracurium,Vecuronium can be used
Atracurium,Vecuronium can be used
• All one needs in this situation is chemical
weakening…
49
• Low pressure,
• High pressure limit and alarm
• Volume alarm(low TV, high and low minute
ventilation)
• High respiratory rate alarm
• Apnea alarm and apnea values
• High/low temperature alarm
• I:E ratio limit and alarm
50
Complications of positive
pressure ventilation
Increase in positive airway pressure
 High intrathorasic pressure
 this pressure transmitted to airway,alveoli,as
well as mediastinum and great vessels
 Compression of great vessels
 Decreased venous return
Decreased strock volume and
cardiac output
Decreased oxygen delivery Hypotension Decreased renal blood flow
decreased GFR
decreased urine output 29
51
Weaning
The process of withdrawing mechanical
ventilatory support and transferring the work of
breathing from the ventilator to patient.
52
 Improvement of the cause of respiratory
failure
 Absence of major system dysfunction
 Appropriate level of oxygenation
 Appropriate level of oxygenation
Adequate ventilatory status
 Intact airway protective mechanism (needed
for extubation)
53
Rapid Shallow Breathing Index
• Failure of weaning may be related to the
development of a spontaneous breathing pattern that
is rapid (high frequency) and shallow (low tidal
volume).
• The rapid shallow breathing index (RSBI) or f/VT
• The rapid shallow breathing index (RSBI) or f/VT
index has been used to evaluate the effectively of
the spontaneous breathing pattern.
• Favourable RSBI is < 105
54
 No one or method of weaning has been
definitely found to be superior;
 Spontaneous Breathing Trial
 Pressure Support Ventilation
Other Modes of Partial Ventilatory Support
 Other Modes of Partial Ventilatory Support
 SIMV
 Volume support (VS) and volume-assured pressure
support (VAPS)
 Mandatory minute ventilation (MMV)
 Airway pressure-release ventilation (APRV)
55
PROCEDU
RE
Steps
PSV 1. PSV may be used in conjunction with spontaneous breathing or
SIMV mode;
2. Start PSV at a level of 5 to 15 cm H2O (up to 40 cm H2O) to
augment spontaneous VT until a desired VT (10 to 15 mL/kg) or
spontaneous frequency (<25/min) is reached;
3. Decrease pressure support (PS) level by 3 to 6 cm H2O intervals
until a level of close to 5 cm H2O is reached;
until a level of close to 5 cm H2O is reached;
4. If patient tolerates step (3), consider extubation when blood gases
and vital signs are satisfactory.
56
What after weaning
• Oxygen therapy
• Close monitoring: ABGs evaluation, Pulse
oximetry
• Bronchodilator therapy
• Bronchodilator therapy
• Chest physiotherapy
• Adequate nutrition, hydration, and humidification
• Incentive spirometry
57
•
Trouble Shooting
Trouble Shooting
58
• The ETT must be repositioned and re-secured at least
once a shift to prevent tissue breakdown
• Mouth care needs to be performed routinely
• Cuff pressure needs to be assessed once a shift
• Sometimes a higher pressure is needed to seal (ETT is
Management of the tube
• Sometimes a higher pressure is needed to seal (ETT is
too small, anatomical differences)
• Check for proper inflation, determine the location of
the leak, assess the integrity of the pilot line
• Suctioning
59
• Every ventilator check must include assessing the
circuit integrity
• PIP and Vt measurements are lower than previous
measurements
Evaluating for Leaks
measurements
• Start at the patient connection and work back to
the ventilator
• May need to disconnect the patient and provide
manual ventilation while testing the circuit
60
 Check plateau pressures by allowing an
inspiratory pause (this gives you the pressure
in the lung itself without the addition of
resistance)
 If peak pressures are high and plateau
 If peak pressures are high and plateau
pressures are low then you have an
obstruction
 If both peak pressures and plateau pressures
are high then you have a lung compliance
issue
61
62
 High peak pressure differential:
High Peak Pressures
Low Plateau Pressures
High Peak Pressures
High Plateau Pressures
Low Plateau Pressures High Plateau Pressures
Mucus Plug ARDS
Bronchospasm Pulmonary Edema
ET tube blockage Pneumothorax
Biting ET tube migration to a
single bronchus
Effusion
63
 Increase in patient agitation and dis-
synchrony on the ventilator:
◦ Could be secondary to overall discomfort
 Increase sedation
◦ Could be secondary to feelings of air hunger
◦ Could be secondary to feelings of air hunger
 Options include increasing tidal volume, increasing
flow rate, adjusting I:E ratio, increasing sedation
64
• Early use of NPPV
• Prepare and expect hypotension during
intubation – IVF bolus
• Mechanical Ventilation Strategy –
Permissive Hypercapnia
• Mechanical Ventilation Strategy –
Permissive Hypercapnia
• Ventilator maneuvers that prolong I:E
– Low tidal volumes, low respiratory rates,
square wave forms, high flow rates.
65
• Tidal Volumes: 6-7 ml/kg (IBW)
• Respiratory Rate: 8-10 bpm
• Flow Rate: 80-100 L/min
• Square Wave forms
• SEDATION: propofol,fentanyl
• Square Wave forms
• SEDATION: propofol,fentanyl
• Last resort: chemical weakening
• Expect high peak pressures
66
 Lung Protective Strategy
 Low-Tidal Volumes
 Start at 6 mL/kg IBW
 Goal of 4-6 mL/kg IBW
Low Plateau Pressures – Less than 30
 Low Plateau Pressures – Less than 30
 High PEEP
 Permissive hypercapnia
67
68

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VENTILATOR BASICS.pdf

  • 1. Dr Siddhartha Sharma Dr Siddhartha Sharma Associate Professor, Department of Anaesthesia, SMS Medical College, Jaipur 1
  • 2.  Mechanical Ventilation is ventilation of the lungs by artificial means usually by a ventilator. ventilator.  A ventilator delivers gas to the lungs with either negative or positive pressure. 2
  • 3.  Negative pressure ventilation Iron lung Chest cuirase Chest cuirase  Positive pressure ventilation Invasive Non invasive 3
  • 4. 1. Relieve respiratory distress 2. Decrease work of breathing 3. Improve pulmonary gas exchange 3. Improve pulmonary gas exchange 4. Reverse respiratory muscle fatigue 5. Permit lung healing 4
  • 5.  Pressure  Volume  Flow  Time 5
  • 6.  Control -the mechanical breath goal, ie, a set pressure or a set volume  Trigger -Variable which starts inspiration Trigger Limit - the maximum permitted value during inspiration.  Cycle - Variable which ends inspiration 6
  • 7. 7
  • 8. Breath types • Mandatory breath Ventilator does the work Ventilator controls start and end of inspiration • Assist control breath patient triggers the breath Venti. Delivers the breath as per control variable 8 Venti. Delivers the breath as per control variable • Spontaneously Supported breath Pt. triggers the breath Ventilator delivers pressure support • Spontaneous Patient takes on work Patient controls start and stop
  • 10. Scalars are waveform representation of pressure,flow,or volume on y axis vrs time on x axis.10
  • 11. 11 11
  • 12.  Indications for ventilator support present  Non-invasive v/s Invasive ventilation  Pressure v/s Volume ventilation  Extent (Partial v/s Full) & mode of ventilation  Extent (Partial v/s Full) & mode of ventilation  Key Ventilatory settings  Appropriate Alarms and Back-up values  Weaning 12
  • 13.  Patient not breathing  Patient breathing, …….but not enough  Patient breathing enough, …….but hypoxemic / hypercapneic  Patient breathing with normal gas  Patient breathing with normal gas exchange, ….but working hard  Airway protection 13
  • 14.  Clinical deterioration  Hypoxia : pO2<60mm Hg  Hypercarbia : pCO2 > 50mm Hg Hypercarbia : pCO2 > 50mm Hg  Tachypnea : RR >35  Tidal volume <3-5 ml/kg  Max. inspiratory pressure <-20 cm H2O 14
  • 16.  Patient continuously receives a set air pressure, during both inspiration and expiration.  Patient has full control over  Patient has full control over respiratory rate, inspiratory time , and depth of inspiration. 16
  • 17.  This provides a set inspiratory pressure and a different set of expiratory pressure  Initial setting: EPAP:5cm H2O IPAP: 8cm H2O O2 @ 2-5 L/min Final IPAP pressures of 15 to 22 cm H2O are common 17
  • 18.  Patient has full control over the respiratory rate, inspiratory time and depth of inspiration IPAP & EPAP can be increased by  IPAP & EPAP can be increased by increments of 2  BiPAP = CPAP + Pressure support during inspiration 18
  • 19. 1.Cardiogenic pulmonary edema , exacerbation of COPD , Post-op respiratory failure. 2.Neuromuscular disease with respiratory muscle weakness, OSA. muscle weakness, OSA. 3.Terminally ill patients & Immuno compromised patients. 4 Weaning mode. 19
  • 20. Advantages: 1 Complications of intubation –avoided 2 Allows speech ,feeding Disadvantages: 1.Patient should be alert with normal 1.Patient should be alert with normal respiratory drive and intact upper airway 2 Cannot protect airway and does not provide full 100% ventillatory support 4 Claustrofobia & uncomfortable for patients 20
  • 21. Improvement in: 1. Respiratory rate and heart rate 2. Dyspnea 2. Dyspnea 3. Oxygen requirement 4. Hypercarbia 21
  • 22.  Provides all the energy for Alveolar Ventilation  Every breath is fully supported by the ventilator  In classic control modes, patients are unable to breathe except at the controlled set rate  In newer control modes, machines may act in  In newer control modes, machines may act in assist-control, with a minimum set rate and all triggered breaths above that rate are also fully supported.  Ensures that patient is not required to do any Work .Of.Breathing 22
  • 23. When to Consider:  Spontaneously breathing patient.  Comfortably provide a portion of their required minute volume required minute volume  Useful for weaning patients from MV support When not to consider:  Should be avoided in case of patients with ventilatory muscle fatigue 23
  • 24. PRESSURE VOLUME Tidal Volume Variable Constant Peak Ins Pressure Constant Variable Dys-synchrony Less More likely Barotrauma Less More likely Flow Pattern Decreasing Preset 24
  • 25.  Balance CO2 removal v/s lung protection  If CO2 clearance more important than lung protection, use VOLUME If lung protection is more important than CO  If lung protection is more important than CO2 removal use PRESSURE  If patient triggered ventilation, synchrony may be enhanced with PRESSURE 25
  • 26.  The ventilator delivers a preset TV at a specific R/R and inspiratory flow rate.  It is irrespective of patients’ respiratory efforts.  In between the ventilator delivered breaths the inspiratory valve is closed so patient doesn’t take additional breaths.  PIP developed depends on lung compliance and respiratory passage resistance. 26
  • 27. 27
  • 28.  Ventilator gives pressure limited, time cycled breaths thus preset inspiratory pressure is maintained. Decelerating flow pattern.  Decelerating flow pattern.  Peak airway/alveolar pressure is controlled but TV, minute volume & alveolar volume depends on lung compliance, airway resistance, R/R & I:E ratio. 28
  • 29. 29
  • 30.  Ventilator assists patient’s initiated breath, but if not triggered, it will deliver preset TV at a preset respiratory rate (control).  Mandatory mechanical breaths may be either  Mandatory mechanical breaths may be either patient triggered (assist) or time triggered (control)  If R/R > preset rate, ventilator will assist, otherwise it will control the ventilation. 30
  • 31. 31
  • 32.  Ventilator delivers either assisted breaths at the beginning of a spontaneous breath or time triggered mandatory breaths.  Synchronization window- time interval just prior to time triggering. prior to time triggering.  Breath stacking is avoided as mandatory breaths are synchronized with spontaneous breaths.  In between mandatory breaths patient is allowed to take spontaneous breath at any TV. 32
  • 33. 33
  • 34.  Patient is spontaneously breathing  The vent augments the patient’s respiratory effort with a “pressure support”  Tidal Volume is determined by patient’s effort and respiratory system compliance Can set a FiO2 PEEP and PS above PEEP  Can set a FiO2 PEEP and PS above PEEP ◦ Can not set respiratory rate except back-up apnea rate. 34
  • 35.  FiO2  Tidal Volume /Pressure  Respiratory Rate PEEP  PEEP  Flow Rate  I:E Ratio  Trigger 35
  • 36. Start with FiO2 =1.0 and titrate to SpO2 >=94% ABG after 20-30min Goal –PaO2 between 60 –100 mmHg If FiO2 requirement is>0.5 , increase PEEP FiO2 =1.0, before & after suction, during bronchoscopy, & any other risky procedure 36
  • 37.  The tidal volume is the amount of air delivered with each breath.  Initial tidal volumes should be 8-10ml/kg, depending on patient’s body habitus.  If patient is in ARDS consider tidal volumes between 4 – 6  If patient is in ARDS consider tidal volumes between 4 – 6 ml/kg with increase in PEEP  In Pressure-Targeted modes you’ll set the Pressure High (PH) according to the delivered tidal volume 37
  • 38.  Males: IBW = 50 kg + 2.3 kg for each inch over 5 feet. Females: IBW = 45.5 kg + 2.3 kg  Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 feet. 38
  • 39.  An optimal method for setting the respiratory rate has not been established.  12 - 15/Min – Adult 20+_ 3 - Child 20+_ 3 - Child 30- 40 - New born On some machines you set the Inspiratory Time (Ti) and Expiratory Time (Te) 39
  • 40.  Increase RR – Hypoxia Hypercapnoea / Resp. Acidosis Sepsis, ARDS, metabolic acidosis Sepsis, ARDS, metabolic acidosis  Decrease RR- Hypocapnoea Resp. Alkalosis Asthma / COPD 40
  • 41. • Minute Ventilation (L/min) = RR (b/min) x Tidal Volume (liters) • If you decrease one or both the MV will • If you decrease one or both the MV will decrease resulting inHypercapnia • Tolerated in status asthmaticus and ARDS/ALI – Called “permissive hypercapnea” 41
  • 42.  A typical initial PEEP applied is 5 cmH2O.  Adjust up by increments of 2 for marked hypoxia However, up to 20 cm H2O used in ARDS  However, up to 20 cm H2O used in ARDS  PEEP increases intra thoracic pressure and can thus decrease venous return and thus Blood Pressure 42
  • 43.  Improves oxygenation Recruits Lung in ARDS Prevents collapse of alveoli Diminishes the work of breathing 43
  • 44.  Peak flow rates of 60 L per minute  Higher rates are frequently necessary in Asthma or those with air hunger  An insufficient peak flow rate is characterized by dysnoea, spuriously low characterized by dysnoea, spuriously low peak inspiratory pressures, and scalloping of the inspiratory pressure tracing  Pressure-Targeted modes allow patient to dictate the flow rate that they want 44
  • 45.  During spontaneous breathing, the normal I:E ratio is 1:2.  If exhalation time is too short “breath stacking” occurs resulting in an increase in end-expiratory pressure also called auto-PEEP.  Asthma/COPD 1:3, 1:4, …  Severe hypoxia ARDS 1:1, 2:1, 45
  • 46.  Most frequently used to obtain an estimate of Plateau pressure and static compliance  Patient should not be actively breathing  When used with each breath, improves distribution of air, V/Q ratio. 46
  • 47.  Pressure triggering -1to -2cm H2O Ventilator-delivered breath is initiated if the demand valve senses a negative airway pressure deflection greater than the trigger sensitivity. Flow triggering  Flow triggering 1 to 3 L/ min (preferred) Continuous flow of gas through the ventilator circuit is monitored. A ventilator delivered breath is initiated when the return flow is less than the delivered flow 47
  • 48. •different medications for sedation. • Opiates (morphine, fentanyl) Benzodiazepines (Midazolam) Opiates (morphine, fentanyl) Benzodiazepines (Midazolam) • Propofol • Less is sometime more 48
  • 49. • Paralysis without sedation = Torture Atracurium,Vecuronium can be used Atracurium,Vecuronium can be used • All one needs in this situation is chemical weakening… 49
  • 50. • Low pressure, • High pressure limit and alarm • Volume alarm(low TV, high and low minute ventilation) • High respiratory rate alarm • Apnea alarm and apnea values • High/low temperature alarm • I:E ratio limit and alarm 50
  • 51. Complications of positive pressure ventilation Increase in positive airway pressure  High intrathorasic pressure  this pressure transmitted to airway,alveoli,as well as mediastinum and great vessels  Compression of great vessels  Decreased venous return Decreased strock volume and cardiac output Decreased oxygen delivery Hypotension Decreased renal blood flow decreased GFR decreased urine output 29 51
  • 52. Weaning The process of withdrawing mechanical ventilatory support and transferring the work of breathing from the ventilator to patient. 52
  • 53.  Improvement of the cause of respiratory failure  Absence of major system dysfunction  Appropriate level of oxygenation  Appropriate level of oxygenation Adequate ventilatory status  Intact airway protective mechanism (needed for extubation) 53
  • 54. Rapid Shallow Breathing Index • Failure of weaning may be related to the development of a spontaneous breathing pattern that is rapid (high frequency) and shallow (low tidal volume). • The rapid shallow breathing index (RSBI) or f/VT • The rapid shallow breathing index (RSBI) or f/VT index has been used to evaluate the effectively of the spontaneous breathing pattern. • Favourable RSBI is < 105 54
  • 55.  No one or method of weaning has been definitely found to be superior;  Spontaneous Breathing Trial  Pressure Support Ventilation Other Modes of Partial Ventilatory Support  Other Modes of Partial Ventilatory Support  SIMV  Volume support (VS) and volume-assured pressure support (VAPS)  Mandatory minute ventilation (MMV)  Airway pressure-release ventilation (APRV) 55
  • 56. PROCEDU RE Steps PSV 1. PSV may be used in conjunction with spontaneous breathing or SIMV mode; 2. Start PSV at a level of 5 to 15 cm H2O (up to 40 cm H2O) to augment spontaneous VT until a desired VT (10 to 15 mL/kg) or spontaneous frequency (<25/min) is reached; 3. Decrease pressure support (PS) level by 3 to 6 cm H2O intervals until a level of close to 5 cm H2O is reached; until a level of close to 5 cm H2O is reached; 4. If patient tolerates step (3), consider extubation when blood gases and vital signs are satisfactory. 56
  • 57. What after weaning • Oxygen therapy • Close monitoring: ABGs evaluation, Pulse oximetry • Bronchodilator therapy • Bronchodilator therapy • Chest physiotherapy • Adequate nutrition, hydration, and humidification • Incentive spirometry 57
  • 59. • The ETT must be repositioned and re-secured at least once a shift to prevent tissue breakdown • Mouth care needs to be performed routinely • Cuff pressure needs to be assessed once a shift • Sometimes a higher pressure is needed to seal (ETT is Management of the tube • Sometimes a higher pressure is needed to seal (ETT is too small, anatomical differences) • Check for proper inflation, determine the location of the leak, assess the integrity of the pilot line • Suctioning 59
  • 60. • Every ventilator check must include assessing the circuit integrity • PIP and Vt measurements are lower than previous measurements Evaluating for Leaks measurements • Start at the patient connection and work back to the ventilator • May need to disconnect the patient and provide manual ventilation while testing the circuit 60
  • 61.  Check plateau pressures by allowing an inspiratory pause (this gives you the pressure in the lung itself without the addition of resistance)  If peak pressures are high and plateau  If peak pressures are high and plateau pressures are low then you have an obstruction  If both peak pressures and plateau pressures are high then you have a lung compliance issue 61
  • 62. 62
  • 63.  High peak pressure differential: High Peak Pressures Low Plateau Pressures High Peak Pressures High Plateau Pressures Low Plateau Pressures High Plateau Pressures Mucus Plug ARDS Bronchospasm Pulmonary Edema ET tube blockage Pneumothorax Biting ET tube migration to a single bronchus Effusion 63
  • 64.  Increase in patient agitation and dis- synchrony on the ventilator: ◦ Could be secondary to overall discomfort  Increase sedation ◦ Could be secondary to feelings of air hunger ◦ Could be secondary to feelings of air hunger  Options include increasing tidal volume, increasing flow rate, adjusting I:E ratio, increasing sedation 64
  • 65. • Early use of NPPV • Prepare and expect hypotension during intubation – IVF bolus • Mechanical Ventilation Strategy – Permissive Hypercapnia • Mechanical Ventilation Strategy – Permissive Hypercapnia • Ventilator maneuvers that prolong I:E – Low tidal volumes, low respiratory rates, square wave forms, high flow rates. 65
  • 66. • Tidal Volumes: 6-7 ml/kg (IBW) • Respiratory Rate: 8-10 bpm • Flow Rate: 80-100 L/min • Square Wave forms • SEDATION: propofol,fentanyl • Square Wave forms • SEDATION: propofol,fentanyl • Last resort: chemical weakening • Expect high peak pressures 66
  • 67.  Lung Protective Strategy  Low-Tidal Volumes  Start at 6 mL/kg IBW  Goal of 4-6 mL/kg IBW Low Plateau Pressures – Less than 30  Low Plateau Pressures – Less than 30  High PEEP  Permissive hypercapnia 67
  • 68. 68