This document summarizes a presentation given by Prof. Dr. Ellen Enkel on how to boost innovation in an economic region. The key points discussed include: (1) Companies need to open up and cooperate with internal and external partners to survive and be innovative; (2) Regions need to foster connectivity between companies, industries, and regions to illustrate available knowledge; and (3) Regions must enable companies to prepare for changing environments and leverage new opportunities arising from technologies, business models, and other factors.