The document outlines 10 key challenges to achieving excellence in Sales and Operations Planning (S&OP). The challenges include: 1) aligning S&OP decisions to business strategy; 2) ensuring business ownership of the S&OP process; 3) aligning reward systems across functions; 4) establishing standardized S&OP metrics; 5) overcoming fear of change; 6) making good cross-functional decisions; 7) tailoring S&OP scenarios to business models; 8) establishing governance over the S&OP process, data, and improvement; 9) fully integrating new product launches; and 10) effectively linking S&OP planning to execution activities.