A hypothesis is a testable statement that predicts a difference or relationship between variables. It should specify the independent and dependent variables and be open to being disproven. There are two types of research hypotheses: directional hypotheses predict a certain direction of effect, while non-directional hypotheses predict only that a difference will occur but not the direction. The null hypothesis is the opposite of the research hypothesis and predicts that any observed difference is due to chance rather than a real effect or relationship between variables.