The document is the proceedings of the 16th International Conference on Project Management and Scheduling held in Rome, Italy from April 17-20, 2018. It contains 65 papers that were accepted for presentation at the conference on topics related to project management and scheduling. The conference was organized by the EURO Working Group on Project Management and Scheduling and had four plenary speakers discussing topics such as comparing event-node graphs with renewable resources and activity-node graphs with nonrenewable resources.