Perforations in the Sub-intimal Space
Dr Andrew Ladwiniec
Consultant Cardiologist
Glenfield Hospital, Leicester, United Kingdom
Friday 2nd September 2022
Honoraria/Speaketr Fees from
Boston Scientific
Teleflex
Disclosure Statement of Financial Interest
How common is it?
Why is it important?
What is different about managing (and avoiding)
sub-intimal perforations?
Sub-intimal perforation
How common is it?
Hirai et al. J Am Coll Cardiol Intv. 2019; 12:1902-12.
Mean J-CTO score: 3.0
Significant calcification: 47%
AWE = 2.8% (18 of 639)
ADR = 7.8% (31 of 400)
RWE = 7.2% (19 of 263)
RDR = 5.9% (21 of 353)
Smith et al. Heart. 2013; 99: 1471-74.
Kinnaird et al. Circ Cardiovasc Interv. 2017; 10:e004642.
Why does it matter?
9 in-hospital deaths in Open CTO due to perforation
1% of cases
10% of perforations
Hirai et al. J Am Coll Cardiol Intv. 2019; 12:1902-12..
The use of sub-intimal
techniques is safe and efficient
Where can it go wrong?
Getting into the sub-intimal space
Traversing the sub-intimal space
Connecting spaces
Ballooning/stenting the sub-intimal space
Getting sub-intimal
Sealing perforations behind a
tissue plane
Spratt JC et al. A guide to mastering antegrade CTO PCI Part 02. Optima. 2019.
Traversing the space
Sizing stents appropriately
Culprit occluded
SVG-RCA
Native CTO
RCA
Spratt JC et al. A guide to mastering antegrade CTO PCI Part 02. Optima. 2019.
Caution when stenting sub-intimally
You can find out late
Perforations happen to us all
The principles of management are well established
Avoidance and treatment can differ slightly if in the
sub-intimal space
In Summary
Perforations happen to us all
The principles of management are well established
Avoidance and treatment can differ slightly if in the
sub-intimal space
In Summary

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Andrew Ladwiniec: Perforations within the subintimal space

  • 1. Perforations in the Sub-intimal Space Dr Andrew Ladwiniec Consultant Cardiologist Glenfield Hospital, Leicester, United Kingdom Friday 2nd September 2022
  • 2. Honoraria/Speaketr Fees from Boston Scientific Teleflex Disclosure Statement of Financial Interest
  • 3. How common is it? Why is it important? What is different about managing (and avoiding) sub-intimal perforations? Sub-intimal perforation
  • 4. How common is it? Hirai et al. J Am Coll Cardiol Intv. 2019; 12:1902-12. Mean J-CTO score: 3.0 Significant calcification: 47% AWE = 2.8% (18 of 639) ADR = 7.8% (31 of 400) RWE = 7.2% (19 of 263) RDR = 5.9% (21 of 353) Smith et al. Heart. 2013; 99: 1471-74.
  • 5. Kinnaird et al. Circ Cardiovasc Interv. 2017; 10:e004642. Why does it matter? 9 in-hospital deaths in Open CTO due to perforation 1% of cases 10% of perforations Hirai et al. J Am Coll Cardiol Intv. 2019; 12:1902-12..
  • 6. The use of sub-intimal techniques is safe and efficient
  • 7. Where can it go wrong? Getting into the sub-intimal space Traversing the sub-intimal space Connecting spaces Ballooning/stenting the sub-intimal space
  • 9. Sealing perforations behind a tissue plane Spratt JC et al. A guide to mastering antegrade CTO PCI Part 02. Optima. 2019.
  • 12. Culprit occluded SVG-RCA Native CTO RCA Spratt JC et al. A guide to mastering antegrade CTO PCI Part 02. Optima. 2019. Caution when stenting sub-intimally
  • 13. You can find out late
  • 14. Perforations happen to us all The principles of management are well established Avoidance and treatment can differ slightly if in the sub-intimal space In Summary
  • 15. Perforations happen to us all The principles of management are well established Avoidance and treatment can differ slightly if in the sub-intimal space In Summary